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Issue 93, 2013
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Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

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Abstract

The corrole-based catalytic antioxidant 1-Fe reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. 1-Fe and a non-redox active analogue of it affect the committed step of the biosynthetic pathway – the HMG-CoA reductase catalysed reaction – by acting as allosteric inhibitors of this key enzyme.

Graphical abstract: Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

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Article information


Submitted
24 Jun 2013
Accepted
25 Jul 2013
First published
26 Jul 2013

Chem. Commun., 2013,49, 10917-10919
Article type
Communication

Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

A. Haber, A. Abu-Younis Ali, M. Aviram and Z. Gross, Chem. Commun., 2013, 49, 10917
DOI: 10.1039/C3CC44740E

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