Issue 40, 2023

Carbon dots-functionalized extended gate organic field effect transistor-based biosensors for low abundance proteins

Abstract

Organic field effect transistors have emerged as promising platforms for biosensing applications. However, the challenge lies in optimizing functionalization strategies for the sensing interface, enabling the simultaneous detection of low abundance proteins while maintaining device performance. Here, we designed a carbon dots-functionalized extended gate organic field effect transistor. Leveraging the advantages of facile synthesis, tunable modification, small particle size, and cost-effectiveness of carbon dots, we implemented their integration onto the electrode surface. Through harnessing the covalent interactions of functional groups on the surface of carbon dots, we achieved effective immobilization of low abundance proteins without compromising device performance. Consequently, this biosensor exhibits a remarkably low limit of detection of 2.7 pg mL−1 and demonstrates high selectivity for the carcinoembryonic antigen. These findings highlight the superior capabilities of carbon dots in enhancing biosensor performance and emphasize their potential for early cancer detection.

Graphical abstract: Carbon dots-functionalized extended gate organic field effect transistor-based biosensors for low abundance proteins

Supplementary files

Article information

Article type
Paper
Submitted
13 Jul. 2023
Accepted
16 Sep. 2023
First published
18 Sep. 2023

Nanoscale, 2023,15, 16458-16465

Carbon dots-functionalized extended gate organic field effect transistor-based biosensors for low abundance proteins

Y. Zhang, C. Sun, Y. Duan, S. Cheng and W. Hu, Nanoscale, 2023, 15, 16458 DOI: 10.1039/D3NR03405D

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