Issue 19, 2019

Total synthesis of (±)-epi-stemodan-13α,17-diol

Abstract

Stemodan-13α,17-diol is a natural stemodane-type diterpenoid isolated from Stemodia chilensis. Herein we report the total synthesis of its epimer, stemodan-13β,17-diol, by applying titanium-mediated polyene cyclization and iron-catalyzed [5 + 2] cycloaddition as the key transformations to expeditiously install the molecular scaffold.

Graphical abstract: Total synthesis of (±)-epi-stemodan-13α,17-diol

Supplementary files

Article information

Article type
Communication
Submitted
21 Mrt. 2019
Accepted
17 Apr. 2019
First published
18 Apr. 2019

Org. Biomol. Chem., 2019,17, 4711-4714

Total synthesis of (±)-epi-stemodan-13α,17-diol

S. Chen, T. Chen, G. Liu, X. Wang, G. Zhu, Y. Liu, S. Fu and B. Liu, Org. Biomol. Chem., 2019, 17, 4711 DOI: 10.1039/C9OB00661C

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