Themed collection Biomaterials Science Open Access Spotlight

We present a translational roadmap for BBB-crossing nanomedicines, integrating transporter-, receptor-, and adsorptive-mediated pathways with disease-specific neuroregenerative demands.

By comparing emerging polycatecholamines with the well-established polydopamine, this perspective expands the horizon of catecholamine-inspired biomaterials across surface modification, bioadhesive, biosensing and drug-delivery applications.

This review evaluates slippery lubricant-infused surfaces (SLIPS) as anti-fouling and antimicrobial coatings, contrasting traditional, smart, and bioactive designs for preventing infection, thrombosis, and device failure.

Hydrogel-based wearable and implantable biosensors have established themselves as a paradigm-shifting platform for continuous health monitoring.

The application of mRNA therapies has witnessed significant advancement since the outbreak of COVID-19.

This review highlights how exosomes and 3D bioprinting together create bioactive scaffolds, enabling sustained release and precise spatial delivery to improve osteochondral, soft tissue, and neural regeneration.

This study comprehensively evaluates intravitreal thermoresponsive, drug-loaded hydrogels, highlighting how polymer composition and therapeutic class influence mechanical properties, safety, and release to guide rational formulation design.

This review introduces recent progress in immune-evasive islet replacement by integrating advances in cell-intrinsic immune engineering with bioengineering strategies that regulate the peri-graft physicochemical milieu.

This review highlights chemical engineering approaches for enhancing the in vivo stability of mRNA–LNP, including sequence engineering, chemical modification, structural optimization and formulation improvement.

This review categorize NO donors into stable and unstable forms, evaluate their merits, and explore strategies for incorporating them into drug delivery systems.

This study introduces an injectable supramolecular hydrogel based on non-covalent interactions between cyclic peptide nanofibers and nanosilicates.

A photoactivatable cell-anchoring surface enables image-guided single-cell isolation through localized light irradiation, allowing rapid and precise isolation of rare cells such as circulating tumor cells (CTCs) from densely populated samples.

Exosome-niosome hybrid oxygen carriers were fabricated as a hepatoprotective agent with anti-hypoxic, antioxidant, and anti-inflammatory properties, and their role in protection from acetaminophen-induced acute liver injury was investigated.

TA extract-mediated biosynthesis produces smaller, bioactive SeNPs with enhanced antioxidant activity and effective ROS scavenging in dermal fibroblasts, offering a safer and cost-effective strategy for antioxidant nanomedicine.

Intrauterine adhesion (IUA) is an important cause of infertility and poses a challenge to women's reproductive health.

Peripheral nerve injury is a common condition and the development of materials that enhance Schwann cell migration to aid in regeneration is critical as the body has a limited ability to repair transected nerves.

Mechanism of preventive tumor vaccines based on hydrogel system.

Adjuvanted mRNA polyplex enhances their immunostimulatory effect.

A multimodal 3D-bioprinting process for fabrication of muscle precursors with high suture retention strength and biofunctionality.

MOF-based arginine nanocarriers enable controlled nitric oxide generation, with enhancing T-cell metabolism and suppressing TNBC cell migration, demonstrating a dual immunometabolic and antitumor strategy.

The increasing prevalence of multidrug-resistant bacteria necessitates innovative antibiotic strategies beyond the discovery of new active compounds.

Novelty: Piezoelectric scaffolds can be coated with both polymeric nanoparticles and soft nanocarriers such as liposomes without requiring covalent surface modification.

Novel bifunctional crystalline nanocellulose bearing both carboxy and dialdehyde groups allows for diamine-based crosslinking for tuneable drug-delivery hydrogels formation.

A zwitterionic CBMA coating grafted onto IOLs creates a highly antifouling surface that inhibits lens epithelial cell adhesion and fibrosis, suppressing posterior capsular opacification.

An injectable hydrogel system composed of amphiphilic copolymers could continuously co-deliver two agents with distinct properties, generating a synergistic effect that effectively inhibited wear particle-induced aseptic inflammation and osteolysis.

Restoring antitumor immunity while enhancing the chemotherapy efficacy represents an optimistic strategy for cancer treatment.

A click-crosslinked dopamine-functionalized hyaluronic acid hydrogel system (Dopa-HA) provides sustained and localized delivery of bioactive molecules, such as extracellular vesicles (EVs), for in situ tissue regeneration.

Multifunctional siRNA nanostructures with supramolecular and photophysical properties exhibit significant intracellular anti-cancer activity, demonstrating their potential for cell biology applications.

Evaluating electronic health records from patients with autoimmune conditions or immunodeficiencies that received biomaterial implants generated potential increased risks for graft complications following procedures.

Oral squamous cell carcinoma (OSCC) is a common cancer of the head and neck, and its treatment outcome depends strongly on whether the tumor is completely removed during surgery.

A ZnO filler and cold atmospheric plasma boost the US response of piezo-PLLA films and improve cell–film contact. Enhanced piezostimulation transfers stimuli more efficiently, increasing antimicrobial activity and promoting human cell proliferation.

Polyamidosaccharides armed with hyaluronic acid disaccharide branches bind the transmembrane glycoprotein cluster of differentiation-44 (CD44), a highly expressed surface receptor that plays a critical role in tumor growth, invasion, and metastasis.

We designed a delivery vehicle that locally maintains recombinant human bone morphogenetic protein-2 (rhBMP-2) at bone surgery sites to enhance bone healing while minimizing excessive bone formation at non-targeted sites.

The design of drug delivery systems (DDS) for efficient and sustained in situ antioxidant treatment is a promising strategy in regenerative medicine applications.

Design, characterization, and extrusion-based 3D printing of acrylate-terminated urethane-based PEG polymers into porous, cytocompatible scaffolds with controlled architecture for patient-specific meniscus implant applications.

Granular hydrogels integrated with three orthogonal click chemistries are engineered to serve as a dynamic tumor microenvironment.

From Voronoi-inspired design to additive manufacturing: a custom tool generates continuous extrusion paths enabling the fabrication of biomimetic scaffolds for in vitro alveolar barrier models.

We find that cadherin-11 (CDH11) serves as a key mediator of lung fibroblast activation on hydrogels by coordinating mechanical and inflammatory cues via both Piezo1 and interleukin-6 (IL-6) signaling.

Silk fibroin scaffolds loaded with growth factors (HGF, FGF-4) reversed chronic liver fibrosis in mice, improving liver function, reducing fibrosis, and promoting tissue regeneration—a promising new approach for treatment.

A glutathione-activatable bola amphiphilic peptide dendrimer exhibits excellent tumor-specific cytosolic siRNA delivery performance with optimized thiol-mediated cellular uptake via dynamic thiol–disulfide exchange.