Themed collection Analytical Methods HOT Articles 2022

A new system termed droplet DNAzyme-coupled rolling circle amplification for single bacteria detection is presented.

Highly-fluorescent carbon dots grown onto dendritic silica nanospheres for immunochromatography to detect anthrax protective antigen.

Determining and quantifying novel impurities and degraded impurities of a drug product is always a continuous challenge to enhancing the drug quality for patients' safety.

A method of quickly and directly identifying bacteria species using LIBS is proposed. It uses filtering, normalization and PCA to preprocess the spectra, uses SVM with one-against-all linear kernel function to establish the prediction model.

Pseudo-ELISA innovative assay based on the combined use of biomimetic receptors (MIP) and antibodies for procalcitonin detection.

Group 13 cations induce hydrolysis of a rhodamine based dye to cause a sharp color change from colorless to pink and a high increment in fluorescence.

Glutathione fluorescent probes based on core–shell structures containing fluorescent dyes, molecularly imprinted materials, and gold nanoparticles are suitable for glutathione sensing in complex materials (such as serum).

By using caffeic acid as the epitope template of chlorogenic acid, the prepared epitope-imprinted MNPs could be applied to the selective separation and extraction of chlorogenic acid and caffeic acid in traditional Chinese medicines.

COFs were grafted with ABEI and applied for building a label-free ECL biosensor for cyt c detection.

Coffee is the most consumed beverage and the second most valuable traded commodity in the world.

SERS was combined with DLLME to develop a rapid and reliable method for the detection and quantification of organophosphorus pesticides, which exhibited good sensitivity and stability for both single and multiple detection of OPPs.

Ribavirin-functionalized AuNP sensors would rapidly change from red to gray when Hg²⁺ was added, and could be applied to detect trace Hg²⁺ with fine selectivity and anti-interference in drinking water.

A new method for identification of AQMs in passenger's luggage using IMS combined with CNN.

MHNTs@ZIF-8 based mSPE-UHPLC-MSMS for the analysis of carbamate pesticides in water.

A bi-electrode sensor with a transition metal oxide-based active layer for electrochemical DNA/RNA amplification detection is developed. The device offers sensitivity towards 10² and 10¹ copies of SARS-CoV-2 plasmid and RNA, respectively.

A paper-based CL gas sensor was established for sensitive detection of trace acetone in exhaled breath. UiO-66 with an adsorption function was in situ synthesized on the paper-based device.

Gold nanoparticles were loaded on metal foam substrates by simple displacement reactions and applied to glucose sensors. The surface charge regulation between Au and Cu stabilized AuOH active site, thus enhanced the glucose sensing performance.

PEI-Cu NCs are successfully obtained for the detection and discrimination of TNT and TNP. Benefitting from excellent sensitivity, high specificity and rapid response time, they are expected to complement large equipment in chemical labs.

A simple method for selective and ultrasensitive determination of citric acid using a CNT/Fe₃O₄-CPE and differential pulse voltammetry was introduced.

Dual-mode sensing with a two-signal read-out is conducive to the improvement of detection accuracy.

The workflow schematic of the proposed sample preparation procedure for iron(III) determination in whole wheat bread, granola, and crispy seaweed samples.

A facile argon (Ar) plasma treatment was employed to enhance the electrocatalytic reactivity of screen-printed carbon electrodes for selective dopamine (DA) detection.

Diuron (DR) as a chemical herbicide that persists in soil and water for a long time and causes extensive harm to humans.

TLC densitometric and RP-HPLC methods for the determination of oxytetracycline and bromhexine with the sensitivity required for their analysis in milk samples accompanied by green profile appraisal.

develop aptamer-regulated CDs for detection of FB₁ by catalytic fluorescence. 2,2′-Dithiosalicylic acid was used to prepare carbon dots catalysing the fluorescence of TMB. Aptamer F10 can bind to FB₁, restoring the catalytic capacity of CDs and increasing fluorescence.

Light scatterometry combined with chemometrics can be a practical approach for the analysis of size and concentration of microplastics in water.

The AuNFs and AuSPs were successfully synthesized for labeling antibodies. The AuSP-ICS and AuNF-ICS were successfully fabricated for sensitive ZEN detection. The AuNF-ICS exhibited satisfactory sensitivity and specificity.

A stripping voltammetric sensor for ultrasensitive detection of artesunate (ART) and dopamine HCl (DA) has been successfully developed using a Ppy@ZnO/Fe₃O₄ core–shell nanocomposite ([PZM])-modified carbon paste sensor (MCPS).

Heavy metal pollution has spread around the world with the development of industry, posing a major threat to human health.

We prepared a one-dimensional (1-D) photonic crystal gel sensor. It has great application potential in the preparation of point-of-care (POC) sensors.

A novel one-step cascade method for galactose detection in neutral conditions was proposed by using a dual-active complex enzyme, which is composed of galactose oxidase and Cu-MOF nanozyme.

A complete protocol is presented for the speciation analysis of ¹²⁹I for both inorganic and organic iodine in seawater using coprecipitation and solid-phase extraction (SPE) combined with accelerator mass spectrometry (AMS).

An innovative fluorescence method has been proposed for enhanced detection of AA based on target-triggered cascade fluorescence recovery of a dual-nanoquencher system.

FTIR-ATR and logistic regression model estimating aging time (shelf life) and detecting frauds of repacking or tampering with labels of roasted coffee.

MTC was prepared and applied to specificly enrich N-glycopeptides based on the synergistic hydrophilic interaction between TA/L-Cys and N-glycopeptides.

The characteristics of CO, HCOOH, C₂H₄, and CH₄ production from CO₂ electroreduction were analyzed by introducing the energy conversion efficiency as a new evaluation standard for electrocatalytic reactions.

Altitude-associated nutrition-compositional evaluation is critical for quality control and value determination of plants.

A 3D-printed multi-modal device was developed to simultaneously detect nitric oxide (NO) and adenosine triphosphate (ATP) in red blood cell suspensions.

The TiO₂@MOF-919(Fe–Cu) solid-phase extraction material was prepared by growing MOF-919(Fe–Cu) in situ on three-dimensional radial TiO₂ microspheres by a simple solvothermal method.

Developed methodology based on simultaneous IDMS and comparison of isotope ratios in ‘twin-blends’ is powerful tool in two-track certification of trace element content in CRMs with matrix requiring total digestion and different extraction procedures.

The hydrolysis of four kinds of vegetable oil was monitored in real-time with ordered porous layer interferometry, which can be used to evaluate the health value of vegetable oil.

The retention behavior of a dangerous toxin, ochratoxin A (OTA), present in food samples and derivatives was evaluated using Layered Double Hydroxides (LDHs).

Chemical derivatization into larger molecules has generated a monoclonal antibody that enables group-specific immunochemical detection of potent methamphetamine and amphetamine enantiomers.

Dual mode chemosensor fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one (FAD) has been reported for simultaneous detection of Zn²⁺ and OCl⁻ by metal coordination and chemodosimetric approach respectively.

This work presents an in-house developed stir bar sorptive extraction (SBSE) device with an XAD-2 adsorbent followed by analysis using GC-FID for the extraction and determination of the five main abused prescription drugs in lean cocktail samples.

A sensitive, specific, and convenient method was developed for SARS-CoV-2 detection using a hot-pack-applied isothermal nucleic acid amplification method.

A paper-based device patterned with a carbon-black–poly(dimethylsiloxane) (PDMS) mixture is developed as a heating platform for nucleic-acid amplification tests.

A lateral flow immunoassay (LFIA) of phycotoxin domoic acid (DA) contaminating seawater and marine organisms was developed in this investigation.

A novel electrochemiluminescence sensor and visual attempts for mercury ion detection were developed by using new functionalized doped quantum dot nano-materials.

The SERS technique has great potential for providing a novel method for effectively and accurately studying the efficacy of the Huo–Xue–Hua–Yu decoction and its drug groups in improving fracture healing.

Chromatographic fingerprinting provides effective technical means for quality evaluation of traditional Chinese medicine.

A method based on few-layer MoS₂ nanosheets for highly sensitive electrochemical detection of tumor marker ctDNA.

Chemical imaging is an important tool for characterising the distribution of components within pharmaceutical tablets. LDIR imaging has shown to be a promising technique for providing high-definition component distribution maps at an order of magnitude faster than traditional methods.

A SERS pH sensor employing Alizarin Yellow R as the molecular probe was developed for use in strong alkaline solutions.

ELISA on microfluidic interface device for lipoarabinomannan.

A paper-based SERS substrate with numerous ‘hotspots’ was fabricated by a simple vacuum filtration method, exhibiting excellent SERS performance for analytes detection.

The legacy use of aqueous film-forming foam (AFFF) has led to the generation of large volumes of per- and poly-fluoroalkyl substances (PFAS)-contaminated asphalt materials, especially at airports and fire training areas.

A two-in-one cationic AIEgen micelle-boosted chemiluminescent H₂O₂ assay with improved sensitivity is presented.

A method for fabricating physically modified silicon nanostructures by combining double-beam double exposure interference lithography with MACE was developed to study the behavior and localization efficiency of SHSY5Y cells on the nanostructures.

In this study, we report a portable kit consisting of a portable workstation, gold screen-printed electrode (SPE), 0.45 μm filter membrane, phosphate buffer solution (PBS), and acetic acid (1%) for point-of-use (POU) analysis of nicotine in tobacco.

An electrochemical biosensing platform for S. typhimurium analysis on the basis of Nt.Bsmal-assisted two-stage signal amplification.

Critical comparison of two in-house analytical methods based on different principles for the detection of pesticide residues in cereals.

The procedure does not require organic solvents and is based on easy CPE of sulphonamides from milk samples. Established limits for total sulphonamides in milk were met using digital images.

Salmonella is one of the most common pathogens associated with food-borne illness resulting from seafood consumption.

Mixed-mode chromatography method offers quantification of TCA carboxylates in cells, human plasma, and plants.

We report a colorimetric sensor array, which uses two nanozymes as electronic tongues for fingerprint identification of six phenols. The six phenols at 50 nM have their own response patterns. The sensor array had distinguished the six phenols in actual samples successfully.

Framework employed to determine human age.

A luminescent MOF (PUC1) was synthesized and applied as chemical sensor for explosives such as PETN and Tetryl with 0.315 and 0.404 μm detection limit.

A reliable smartphone imaging spectrometer developed foron-site food freshness testing offers portability, CMOS compatibility, enhanced near-infrared spectrum capture capability and on-the-go (OTG) functionality.

A method based on analyzing the autocorrelation function of the dynamic light scattering is developed to investigate protein diffusivities in diluted protein/solvent binary systems and diluted protein/hyaluronic acid/solvent ternary systems.