Issue 5, 2023

Photoredox-catalyzed sequential Dowd–Beckwith ring expansion and C–H functionalization of THIQs

Abstract

An efficient tandem Dowd–Beckwith ring expansion/C–H functionalization of tetrahydroisoquinolines (THIQs) upon photocatalysis is disclosed, providing a unique idea to connect important medium-sized cycloalkanones with THIQ skeletons, along with the construction of an all-carbon quaternary carbon center. This protocol features step- and atom-economy, mild conditions and good functional group tolerance.

Graphical abstract: Photoredox-catalyzed sequential Dowd–Beckwith ring expansion and C–H functionalization of THIQs

Supplementary files

Article information

Article type
Research Article
Submitted
17 Kax 2022
Accepted
14 Qun 2023
First published
17 Qun 2023

Org. Chem. Front., 2023,10, 1147-1152

Photoredox-catalyzed sequential Dowd–Beckwith ring expansion and C–H functionalization of THIQs

H. Xin, L. Guo, M. Yang, C. Guan, Z. Yuan and X. Duan, Org. Chem. Front., 2023, 10, 1147 DOI: 10.1039/D2QO02001G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements