Issue 16, 2018

Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

Abstract

A highly efficient copper-catalyzed oxidative functionalization of benzylic C(sp3)–H bonds with quinazoline 3-oxides was described. This protocol provides a broad range of quinazolin-4(3H)-one derivatives in good to excellent yields using a Cu/TBHP oxidation system. A plausible reaction mechanism involving radical species is proposed to rationalize the experimental results.

Graphical abstract: Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

Supplementary files

Article information

Article type
Research Article
Submitted
13 Qas 2018
Accepted
11 Qad 2018
First published
12 Qad 2018

Org. Chem. Front., 2018,5, 2492-2495

Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

L. Fan, Z. Zhang, T. Wang, Q. Liang and J. Zhao, Org. Chem. Front., 2018, 5, 2492 DOI: 10.1039/C8QO00588E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements