Issue 2, 2016

Stereocontrol within polyketide assembly lines

Abstract

Covering: 2006 to 2015

Most of the stereocenters of polyketide natural products are established during assembly line biosynthesis. The body of knowledge for how stereocenters are set is now large enough to begin constructing physical models of key reactions. Interactions between stereocenter-forming enzymes and polyketide intermediates are examined here at atomic resolution, drawing from the most current structural and functional information of ketosynthases (KSs), ketoreductases (KRs), dehydratases (DHs), enoylreductases (ERs), and related enzymes. While many details remain to be experimentally determined, our understanding of the chemical and physical mechanisms utilized by the chirality-molding enzymes of modular PKSs is rapidly advancing.

Graphical abstract: Stereocontrol within polyketide assembly lines

Article information

Article type
Highlight
Submitted
11 Leq 2015
First published
19 Xim 2015

Nat. Prod. Rep., 2016,33, 141-149

Author version available

Stereocontrol within polyketide assembly lines

A. T. Keatinge-Clay, Nat. Prod. Rep., 2016, 33, 141 DOI: 10.1039/C5NP00092K

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