Catalyst-free cross-coupling of N-tosylhydrazones with chromium(0) Fischer carbene complexes: a new approach to diarylethanone

Abstract

Cross-coupling of N-tosylhydrazones with chromium Fischer carbene complexes under catalyst-free conditions has been developed. This protocol employs stable carbene complexes and reactive diazo compounds, which are in situ generated from N-tosylhydrazones. Through hydrolysis of the initially formed methyl enolate products, the diarylethanone derivatives could be obtained in moderate to good yields.