Issue 58, 2016

Bioreductive fluorescent imaging agents: applications to tumour hypoxia

Abstract

Large tumours contain regions with very low intracellular O2 concentrations. Known as hypoxia, this feature of tumours yields a highly reducing environment owing to the presence of numerous oxygen sensitive reductase enzymes. The development of new optical chemosensors for these various reductases presents an ideal approach to visualise areas of hypoxia or highly reducing environments. Critical to the success of such chemosensors is the design of probes containing a bioreductively activated moiety that either ensures the selective retention of fluorescence within a hypoxic tissue or a probe that irreversibly releases a reporter fluorophore. This Feature Article aims to summarise the fluorescent tools that have been developed to image tumour hypoxia and the various reductase enzymes associated with the bioreduction process.

Graphical abstract: Bioreductive fluorescent imaging agents: applications to tumour hypoxia

Article information

Article type
Feature Article
Submitted
01 Nah 2016
Accepted
19 Nah 2016
First published
19 Nah 2016

Chem. Commun., 2016,52, 8935-8956

Bioreductive fluorescent imaging agents: applications to tumour hypoxia

R. B. P. Elmes, Chem. Commun., 2016, 52, 8935 DOI: 10.1039/C6CC01037G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements