Themed collection 2025 Pioneering Investigators

Photoactivated nanovaccines
Photoactivated nanovaccines enhance immune responses through light-controlled antigen release and phototherapy-induced ICD for cancer and infection treatment.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00608B

Electrochemical power sources enabled by multi-ion carriers
This review offers a comprehensive overview of electrochemical devices enabled by multi-ion carriers, highlighting synergistic ion transport, interfacial stabilization, and hybrid redox mechanisms that overcome single-ion system limitations.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00785B
Small-molecule photoacoustic probes for in vivo imaging
This review summarizes advances in small-molecule photoacoustic probes, detailing their design, properties, and applications in detecting key bioactive species, and highlights challenges and future directions for molecular imaging development.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00745C
Advancements in polymer materials for high-energy-density lithium-ion batteries
The application of polymer materials in high-energy-density lithium-ion batteries.
Chem. Soc. Rev., 2025,54, 8287-8324
https://doi.org/10.1039/D5CS00583C
Advances in N-heterocyclic carbene organocatalysis from 2015 to 2024
The key progress in the field of N-heterocyclic carbene (NHC) organocatalysis during the period of 2015 to 2024 is systematically summarized and discussed in this review.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00600G
Single- and multi-modal molecular probes with second near-infrared activatable optical signals for disease diagnosis and theranostics
This review highlights the recent advances in single- and multi-modal molecular probes with NIR-II activatable optical signals for disease diagnosis and theranostics.
Chem. Soc. Rev., 2025,54, 7561-7609
https://doi.org/10.1039/D5CS00502G
Navigating the functionalization of unactivated alkenes via visible light photocatalysis
Direct functionalization of unactivated alkenes via visible-light photocatalysis has emerged as a highly effective strategy for the rapid construction of multi-functional, complex molecular architectures from simple, abundant chemicals.
Chem. Soc. Rev., 2025,54, 6726-6806
https://doi.org/10.1039/D5CS00181A

Bis(trimethylsilyl)phosphide chemistry: a half-century of advances across the periodic table
We review structurally authenticated metal(loid) bis(trimethylsilyl)phosphide complexes, highlighting how their solid-state structures and electronic structures differ from those containing the related bis(trimethylsilyl)amide ligand.
Chem. Soc. Rev., 2025,54, 3819-3847
https://doi.org/10.1039/D4CS01141D
Defining, designing and determining the structure of supramolecular frameworks
This Tutorial Review provides an introduction to the field of porous frameworks assembled through directional noncovalent interactions. In it we suggest a coherent naming system for these materials and propose standards for their characterisation.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00550G
Ligand relay catalysis: concepts, principles, and applications in transition-metal catalysis
This review highlights ligand relay catalysis, a strategy that employs dynamic ligand exchange to circumvent the limitations of single-ligand systems, thereby enabling superior reactivity, selectivity, and novel transformations.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00806A
Three-phase microenvironment modification by optimizing ionomer towards high-performance proton exchange membrane fuel cells
This review summarizes proton, water, and oxygen transport in ionomers of PEMFCs and highlights design strategies to optimize the three-phase boundary, enhancing mass transport, performance, and future prospects.
Chem. Soc. Rev., 2025, Advance Article
https://doi.org/10.1039/D5CS00604J
About this collection
To complement our biennial Emerging Investigators collection, we are delighted to present the 2025 Pioneering Investigators collection. This special collection showcases high quality research being carried out by international researchers who are more established in their independent careers and have been recognised as making a significant contribution to their field.
New articles will be added to this collection as they are published.