Issue 19, 2024

Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review

Abstract

Epoxides are oxygen containing heterocycles which are significantly employed as crucial intermediates in various organic transformations. They are considered highly reactive three-membered heterocycles due to ring strain and they undergo epoxide ring opening reactions with diverse range of nucleophiles. Epoxide ring-opening reactions have gained prominence as flexible and effective means to obtain various functionalized molecules. These reactions have garnered substantial attention in organic synthesis, driven by the need to comprehend the synthesis of biologically and structurally important organic compounds. They have also found applications in the synthesis of complex natural products. In this review article, we have summarized the implementation of epoxide ring opening reactions in the synthesis of alkaloids and terpenoids based natural products reported within the last decade (2014–2023).

Graphical abstract: Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review

Article information

Article type
Review Article
Submitted
10 Mar 2024
Accepted
15 Apr 2024
First published
23 Apr 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 13100-13128

Exploring the synthetic potential of epoxide ring opening reactions toward the synthesis of alkaloids and terpenoids: a review

M. Hanif, A. F. Zahoor, M. J. Saif, U. Nazeer, K. G. Ali, B. Parveen, A. Mansha, A. R. Chaudhry and A. Irfan, RSC Adv., 2024, 14, 13100 DOI: 10.1039/D4RA01834F

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