RSC Advances  

An anticancer proligand, with AIEE features, demonstrates exceptional binding efficiencies with DNA and SARS-CoV-2 and offers as a promising bioprobe.

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of the nanoparticle-hydrogels system for the delivery of antimicrobial agents.

The global community is faced with numerous health concerns such as cancer, cardiovascular and neurological diseases, diabetes, joint pain, osteoporosis, among others.

We have designed and screened seven fully 2′-O-methyl phosphorothioate-modified steric-blocking ASOs for specific inhibition of BIRC5 expression. As a result, ASO-7 was identified as the lead sequence.

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

A novel protocol for introducing an acetoxy functional group selectively on the ortho aryl sp² carbon of 2-aryloxyquinoline-3-carbaldehydes in good yields with good functional group tolerance using a palladium catalyst was developed for the first time.

This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2 inhibitors as potential treatments.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

Predict SLC6 mutation clinical pathogenicity by calculating the amino acid descriptors in different ranges with rationalization analysis of the prediction.

HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.

Most MOFs for controllable cancer treatment act as drug delivery vehicle and/or anti-cancer agent. Molecules with anti-cancer roles such as chemotherapies, gases, peptides or nucleic acids can be loaded into MOFs that decompose in cancer cells or in the TME to release its cargoes.

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Twelve compounds were isolated from Mussaenda saigonensis aerial parts through phytochemical analysis and the genus Mussaenda is the first place where the compounds 4–6 and 11–12 have been found.

This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease.

Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.

Spirooxindolopyrrolidines were synthesized in quantitative yield through cycloaddition strategy. Compounds exhibited significant anti-tubercular activity and molecular docking studies of the compound is well correlates with in vitro findings.

Modified niosomes possessing pH-responsive properties were developed for delivery of antineoplastic agents.

Zymosan/ι-carrageenan/agarose hydrogel (antitumor) as tumor targeting (M2 to M1 genes) and wound healing material.

A sequence of novel quinoline-8-yloxy and cinnamide hybrids has been synthesized and evaluated for in vitro cytotoxicity against HepG2 liver cancer cells.

Our study introduces novel symmetrical and asymmetrical dihydropyridines as breast cancer inhibitors, showing cytotoxicity against MCF-7 cells and EGFR kinase inhibition. Molecular docking and dynamics validate superior binding to Lapatinib.

Novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent apoptotic inducers as PIM-1 kinase inhibitors.

Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.

Hydrazone-based polyhydroquinoline derivatives are synthesized and characterized through modern spectroscopic techniques, compounds showed high potency and inhibitory activity. Molecular docking and DFT analyses were performed to predict structure activity relationship, electronic properties etc.

The cWIWLYA peptide shows high labeling efficiency with I-131 (>90%). Its ¹³¹I₂-complex has high stability at room temperature as well as in plasma.