RSC Advances  

The global community is faced with numerous health concerns such as cancer, cardiovascular and neurological diseases, diabetes, joint pain, osteoporosis, among others.

We have designed and screened seven fully 2′-O-methyl phosphorothioate-modified steric-blocking ASOs for specific inhibition of BIRC5 expression. As a result, ASO-7 was identified as the lead sequence.

A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.

This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2 inhibitors as potential treatments.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Twelve compounds were isolated from Mussaenda saigonensis aerial parts through phytochemical analysis and the genus Mussaenda is the first place where the compounds 4–6 and 11–12 have been found.

A sequence of novel quinoline-8-yloxy and cinnamide hybrids has been synthesized and evaluated for in vitro cytotoxicity against HepG2 liver cancer cells.

Our study introduces novel symmetrical and asymmetrical dihydropyridines as breast cancer inhibitors, showing cytotoxicity against MCF-7 cells and EGFR kinase inhibition. Molecular docking and dynamics validate superior binding to Lapatinib.

Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.

Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD).

Through in silico methods, three fungal metabolites, namely cochlactone A, antcamphin M, and methyl ganoderate E, exhibited potential multi-target inhibitory activity against African swine fever virus (ASFV) base excision repair proteins.

Proaporphine alkaloids—cissamaline, cissamanine, and cissamdine—show promise against AD, with in silico studies highlighting their potential as new therapeutics.

The new classification of APAP combinations (prodrugs, codrugs, and hybrids) was proposed. It makes a better understanding of the SAR studies for new pain relievers research and the design development for the analgesic APAP-based compounds.

DDAH1 inhibitors with diverse chemical structures are needed for the development of new therapeutics in NO related disorders.

Polymer–DNA assembled nanoflower for targeted delivery of dolastatin-derived microtubule inhibitors was developed, and it exhibited increased cellular uptake and enhanced inhibitory effect, especially in multidrug-resistant tumor cell.

New pyrimidine-based carbocylic nucleoside derivatives with C-4 substitution for inhibiting α-glucosidase as a means of alleviating the effects of diabetes mellitus (DM) and microbial infections.

This study demonstrated that an arctigenin derivative B7 induced apoptosis in leukemia MV411 cells by enhancing histone acetylation levels and activating the Caspase-3 pathway.

Sulfobutylether β-cyclodextrin can significantly improve the antioxidant and antibacterial activities of quercetin through the formation of an inclusion complex, and their interactions have been elucidated.

Integrase plays an important role in the life cycle of HIV-1, and indole-2-carboxylic acid derivative 17a can effectively inhibit the strand transfer of integrase.

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple enzymes involved.

Two QSAR models which correlates the interaction energy and structural features of agonists and antagonists of M1-AChR.

Recently, new pharmaceutical discoveries have become very important for addressing diverse health problems and protecting humanity.

A sustainable and environmentally friendly approach was devised for the synthesis of bioactive hybrids, which were subsequently assessed for their antimicrobial efficacy.