RSC Advances  

This work employed a biocompatible and synthetic-based thermo-responsive material with tailored mechanical properties as a potential macro-scale scaffold to support ex vivo T and CAR-T cell encapsulation and culture.

Scientists have established a connection between environmental exposure to toxins like β-N-methylamino-L-alanine (BMAA) and a heightened risk of neurodegenerative disorders.

Alginate-based bioinks used for DoD approaches can be modified with specific peptide-containing components so that incorporated printed cells show significantly higher cell elongation ratios after 7 days (created with https://www.BioRender.com).

NIR fluorescence-guided PDT offers deep tissue penetration & real-time monitoring, enabling precise tumor treatment with minimal side effects, making it a promising approach for cancer therapy.

In this study, the PDA-Cur NPs has been successfully synthesized and proved to be an anticancer agent with better photostability and increased utilization of curcumin in PDT.

An anticancer proligand, with AIEE features, demonstrates exceptional binding efficiencies with DNA and SARS-CoV-2 and offers as a promising bioprobe.

Nanoparticle-hydrogel systems are versatile biomaterials that possess numerous advantages for biomedical applications. This review focuses on the application of the nanoparticle-hydrogels system for the delivery of antimicrobial agents.

The global community is faced with numerous health concerns such as cancer, cardiovascular and neurological diseases, diabetes, joint pain, osteoporosis, among others.

We have designed and screened seven fully 2′-O-methyl phosphorothioate-modified steric-blocking ASOs for specific inhibition of BIRC5 expression. As a result, ASO-7 was identified as the lead sequence.

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

A novel protocol for introducing an acetoxy functional group selectively on the ortho aryl sp² carbon of 2-aryloxyquinoline-3-carbaldehydes in good yields with good functional group tolerance using a palladium catalyst was developed for the first time.

A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.

This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2 inhibitors as potential treatments.

The UV-crosslinkable benzophenone (BP) “bio-glue” efficiently crosslinks with various surfaces and biomolecules. The beauty of this bio-glue lies in its simplicity and broad applicability, requiring no sophisticated equipment or reaction conditions.

Disulfiram (DSF) can target and kill cancer cells by disrupting cellular degradation of extruded proteins and has therefore received particular attention for its tumor chemotherapeutic potential.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

Predict SLC6 mutation clinical pathogenicity by calculating the amino acid descriptors in different ranges with rationalization analysis of the prediction.

Five new homoleptic derivatives of titanium(IV) have been developed and characterized by physicochemical techniques.

Illustration of the mechanism of NbC/TA–GelMA hydrogel with multifunctional properties for potential application in oral mucosal impairment.

A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.

HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.

Most MOFs for controllable cancer treatment act as drug delivery vehicle and/or anti-cancer agent. Molecules with anti-cancer roles such as chemotherapies, gases, peptides or nucleic acids can be loaded into MOFs that decompose in cancer cells or in the TME to release its cargoes.

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Twelve compounds were isolated from Mussaenda saigonensis aerial parts through phytochemical analysis and the genus Mussaenda is the first place where the compounds 4–6 and 11–12 have been found.