RSC Advances  

The dimerization of the Aβ₄₂ peptide is inhibited by the silver nanoparticle.

Pregnenolone-based derivatives have been synthesized to inhibit the protofibril formation in order to reduce Aβ_1–42 production and prevent its aggregation.

In this study, we prepare pore-spanning membranes that mimic the composition of plasma membranes and perform force spectroscopy indentation measurements to unravel mechanistic insights depending on lipid composition.

A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.

WAXS displays a significant difference due to the presence of amyloid fibrils in the absence of sugar.

A versatile probe with mitochondria targeting, PN, for detection of viscosity alteration in HIRI mouse model was fabricated. PN had high sensitivity and selectivity, and with a large Stokes shift (∼190 nm) for viscosity. PN is expected to be used for early diagnosis and treatment assessment of HIRI disease, and also provides diagnostic basis for other related diseases.

This review summarized the function of cancer cell membranes and comprehensively discussed the preparation of cancer cell membrane-coated nanoparticles (CCM-NPs) and their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Two QSAR models which correlates the interaction energy and structural features of agonists and antagonists of M1-AChR.

Silica-coated lanthanide-doped upconverting nanoparticles (UCNPs) are internalized by mammalian cells. The bipyramidal UCNPs are non-toxic and elicit minor stress responses in a cell type-dependent fashion.

The fundamentals of bio-orthogonal click chemistry are investigated, while exploring mechanistic intricacies, demonstrating the adaptability and promise of this methodology.

Lipid nanodisc is a promising nano-carrier for molecular delivery that efficiently delivers hydrophobic molecules to intact cells.

A single-molecule electrophysiology assay was employed using an α-HL nanopore to test the stability of ssDNA and gp32 SSB–protein, in different salt conditions. Low salt and the presence of Zn²⁺ increases ssDNA–gp32 complex stability.

A deep learning approach centered on electron density is suggested for predicting the binding affility between proteins and ligands. The approach is thoroughly assessed using various pertinent benchmarks.

De novo designed aliphatic and aromatic peptides form biomimetic supramolecular nanofibrils illuminating the intricacies of the pathogenic amyloid assemblies.

The recovery rate of the fluorescein sodium-loaded carbomer film following a prolonged bleaching process demonstrates a conspicuous deceleration at elevated concentrations.

Despite many reports detailing silk hydrogels, the development of composite silk hydrogels with homotypic and heterotypic silk nanoparticles and their impact on material mechanics and biology have remained largely unexplored.

We developed modular antimicrobial compounds capable of inducing cytoplasmic membrane perforation. This structure–activity relationship study focuses on the role of the length of their alkenyl hydrophobic module.

Indirect labelling of the lipopolysaccharide of Gram-negative bacteria by fluorescence turn-on signalling and computational calculations.

Amyloid proteins displaying a copper histidine-brace offer designable scaffolds for efficient and asymmetric chemical reactions.

Decoding arsenic's impact: data mining protein structures in the protein data bank through amino acid mapping.

In this review, we have discussed some features of protein aggregation during production, formulation and storage as well as stabilization strategies in protein engineering and computational methods to prevent aggregation.

Classical interaction energies as a function of the distance between the AuNP and proteins have Lennard-Jones-like potentials.

Using SARS-CoV-2 M^pro as a case study, Wasserstein distance and dimension reduction are applied to the analysis of MD data of flexible complexes. The resulting embedding map correlates ligand-induced conformational differences and binding affinity.

Antimicrobial peptides (AMPs), naturally-occurring peptide antibiotics, are known to attack bacteria selectively over the host cells.

Binding interactions of fluorescent flavonols with the β-glucosidase enzyme are studied using fluorescence spectroscopy in combination with molecular docking and molecular dynamics simulations.