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Themed collection Chemical Biology

26 items
Perspective

The right touch: design of artificial antigen-presenting cells to stimulate the immune system

In this review we discuss the rapid developments on artificial structures meant to manipulate the immune system.

Graphical abstract: The right touch: design of artificial antigen-presenting cells to stimulate the immune system
From the themed collection: Chemical Biology
Perspective

Inteins: nature's gift to protein chemists

Inteins are a unique class of auto-processing domains with numerous applications in protein engineering and chemical biology.

Graphical abstract: Inteins: nature's gift to protein chemists
From the themed collection: Chemical Biology
Perspective

Realizing the promise of chemical glycobiology

This review highlights recent advances and identifies the challenges and opportunities in chemical glycobiology, an emerging subfield of chemical biology.

Graphical abstract: Realizing the promise of chemical glycobiology
From the themed collection: Chemical Biology
Open Access Perspective

Synthetically defined glycoprotein vaccines: current status and future directions

We highlight current glycovaccines in the clinic and derive principles for the construction of the next generation of synthetically defined glycoconjugate vaccines.

Graphical abstract: Synthetically defined glycoprotein vaccines: current status and future directions
From the themed collection: Chemical Biology
Perspective

On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates

Chemistry meets biology: parallels between covalent intermediates in chemical glycosylation and enzymatic glycoside hydrolysis reactions.

Graphical abstract: On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: trapped covalent intermediates
From the themed collection: Chemical Biology
Perspective

Chemical biology toolkit for exploring protein kinase catalyzed phosphorylation reactions

Protein kinases catalyzed phosphorylations of peptide and protein substrates.

Graphical abstract: Chemical biology toolkit for exploring protein kinase catalyzed phosphorylation reactions
From the themed collection: Chemical Biology
Perspective

Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology

The trimethyl lock provides unmatched attributes as a trigger for the release of small molecules by an enzymatic, chemical, or photolytic process.

Graphical abstract: Trimethyl lock: a trigger for molecular release in chemistry, biology, and pharmacology
From the themed collection: Chemical Biology
Perspective

Hydrogenases and oxygen

We summarize the current picture of oxygen-induced inhibition of the different classes of hydrogenases and discuss possible avenues that might lead to tailored oxygen-robust enzyme variants.

Graphical abstract: Hydrogenases and oxygen
From the themed collection: Chemical Biology
Minireview

Glucose conjugation for the specific targeting and treatment of cancer

This minireview discusses current progress in, and important considerations for, the emerging field of glycoconjugated anticancer therapeutics.

Graphical abstract: Glucose conjugation for the specific targeting and treatment of cancer
From the themed collection: Chemical Biology
Open Access Minireview

Enzyme inhibition by metal complexes: concepts, strategies and applications

Metal complexes are increasingly being used to inhibit enzymes.

Graphical abstract: Enzyme inhibition by metal complexes: concepts, strategies and applications
From the themed collection: Chemical Biology
Minireview

Dressed for success – applying chemistry to modulate aptamer functionality

Chemical modifications modulate aptamer functionality and help to assert their full application potential.

Graphical abstract: Dressed for success – applying chemistry to modulate aptamer functionality
From the themed collection: Chemical Biology
Minireview

Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?

An overview of the studies concerning the interactions of platinum anticancer agents with proteins/peptides is provided.

Graphical abstract: Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry?
From the themed collection: Chemical Biology
Open Access Edge Article

DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides

The pyrazole and salen ligandosides, when combined, are able to create stable multi-copper ion complexing DNA duplex structures in a cooperative fashion.

Graphical abstract: DNA based multi-copper ions assembly using combined pyrazole and salen ligandosides
Edge Article

Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover

A RNA triggered chemical peptidyl transfer reaction leads to a cytotoxic peptide conjugate that requires turnover in RNA for bioactivity.

Graphical abstract: Cytotoxic peptide–PNA conjugates obtained by RNA-programmed peptidyl transfer with turnover
From the themed collection: Chemical Biology
Edge Article

Functionalised staple linkages for modulating the cellular activity of stapled peptides

A divergent synthetic strategy for generating helical p53 peptides bearing functionalised staple linkages, allowing for efficient optimisation of cellular activity.

Graphical abstract: Functionalised staple linkages for modulating the cellular activity of stapled peptides
From the themed collection: Chemical Biology
Edge Article

Chemoenzymatic exchange of phosphopantetheine on protein and peptide

Evaluation of new acyl carrier protein hydrolase homologs from proteobacteria and cyanobacteria reveals significant variation in substrate selectivity and kinetics.

Graphical abstract: Chemoenzymatic exchange of phosphopantetheine on protein and peptide
From the themed collection: Chemical Biology
Open Access Edge Article

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

Structure-dependent anticancer activity of metallo-helices, novel interactions with potential drug targets, and evidence of an apoptotic mechanism are presented.

Graphical abstract: Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
From the themed collection: Chemical Biology
Edge Article

Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers

Dityrosine-linked Aβ dimers have been synthesized and display decreased rates of fibrilization and increased neuronal cell toxicity compared with the corresponding monomeric peptides.

Graphical abstract: Synthetic dityrosine-linked β-amyloid dimers form stable, soluble, neurotoxic oligomers
From the themed collection: Chemical Biology
Edge Article

Specific recognition of DNA depurination by a luminescent terbium(III) complex

A terbium(III) complex exhibits sensitive luminescence response to purine bases in DNA, which can be used to recognize DNA depurination as a selective time-resolved luminescence probe.

Graphical abstract: Specific recognition of DNA depurination by a luminescent terbium(iii) complex
From the themed collection: Chemical Biology
Edge Article

Responsive MR-imaging probes for N-methyl-D-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy

MR Imaging probes for NMDA receptors on a hybrid NSC-34 cell line show relaxation enhancements; the receptors have been visualised by microscopy and the specificity and reversibility of binding demonstrated.

Graphical abstract: Responsive MR-imaging probes for N-methyl-d-aspartate receptors and direct visualisation of the cell-surface receptors by optical microscopy
From the themed collection: Chemical Biology
Open Access Edge Article

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells

A cyclic peptide inhibitor of the CtBP transcription repressor, discovered using a genetically encoded HTS platform, is used to link upregulated glycolytic flux to cell-cycle regulation in tumors.

Graphical abstract: A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
From the themed collection: Chemical Biology
Edge Article

Chemical fidelity of an RNA polymerase ribozyme

We challenge a polymerase ribozyme with an array of nucleotide variants to assess its tolerance of substrate heterogeneity. We uncover specificity determinants, and describe the implications for primordial RNA replication.

Graphical abstract: Chemical fidelity of an RNA polymerase ribozyme
From the themed collection: Chemical Biology
Edge Article

Direct hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules

Primary carbons of propane and ethane are hydroxylated under high-pressure conditions of the alkanes (0.5 MPa) by wild-type P450BM3.

Graphical abstract: Direct hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules
From the themed collection: Chemical Biology
Edge Article

Remodeling a β-peptide bundle

We apply the Rosetta algorithm to repack the hydrophobic core of a β-peptide bundle while retaining both structure and stability.

Graphical abstract: Remodeling a β-peptide bundle
From the themed collection: Chemical Biology
Edge Article

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase

To test the hypothesis that FAAH recruits its hydrophobic substrates directly from the cellular lipid bilayer, we have created clickable, photoreactive inhibitors that enable exploration of the enzyme's active site microenvironment in native cellular membranes.

Graphical abstract: Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase
From the themed collection: Chemical Biology
Edge Article

A dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients produced in living cells

We present a modular dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients in the phagosomes of RAW 264.7 macrophages during immune insult.

Graphical abstract: A dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients produced in living cells
From the themed collection: Chemical Biology
26 items

About this collection

Looking for the best articles at the chemistry-biology interface? Associate Editors Professor Ben Davis and Professor Tom Muir, have picked some of their favourite articles recently published in Chemical Science. The collection showcases some of the great research papers and reviews published in Chemical Science in the areas of chemical biology and bioinorganic chemistry.

Spotlight

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