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Themed collection In Vivo Systems Biology

5 items
Review Article

Systems biology of neurodegenerative diseases

Systems biology is a powerful tool for deciphering complex mechanisms driving neurodegenerative diseases.

Graphical abstract: Systems biology of neurodegenerative diseases
From the themed collection: In Vivo Systems Biology
Review Article

Multiscale analysis of the murine intestine for modeling human diseases

When functioning properly, the intestine is one of the key interfaces between the human body and its environment.

Graphical abstract: Multiscale analysis of the murine intestine for modeling human diseases
From the themed collection: In Vivo Systems Biology
Review Article

Systems biology of the microvasculature

Integrated multi-scale physiological models are used to simulate the maintenance, pathological disruption, and therapeutic rebalancing of vascular networks.

Graphical abstract: Systems biology of the microvasculature
From the themed collection: In Vivo Systems Biology
Paper

A multi-scale approach to designing therapeutics for tuberculosis

Computational models constructed by integrating data from multiple model systems are used to investigate antibiotic, cytokine, and vaccine therapies.

Graphical abstract: A multi-scale approach to designing therapeutics for tuberculosis
From the themed collection: In Vivo Systems Biology
Frontier

Abstracting the principles of development using imaging and modeling

Developmental biology is entering a quantitative era that calls for a balanced investigation approach that integrates imaging, modeling and perturbation.

Graphical abstract: Abstracting the principles of development using imaging and modeling
From the themed collection: In Vivo Systems Biology
5 items

About this collection

A broadly relevant understanding of biology at the organismal level requires approaches that allow for the collection and interpretation of complex datasets derived from whole organisms. This can be achieved through the integrated experimental and computational approaches of systems biology. This issue of Integrative Biology guest edited by Doug Lauffenburger and Kevin Haigis will highlight recent efforts to apply computational modelling approaches to complex in vivo experimental systems and provide insights into how similar approaches may help us to understand organismal biology in a way that is unprecedented.

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