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Issue 5, 2015
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A multi-scale approach to designing therapeutics for tuberculosis

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Abstract

Approximately one third of the world's population is infected with Mycobacterium tuberculosis. Limited information about how the immune system fights M. tuberculosis and what constitutes protection from the bacteria impact our ability to develop effective therapies for tuberculosis. We present an in vivo systems biology approach that integrates data from multiple model systems and over multiple length and time scales into a comprehensive multi-scale and multi-compartment view of the in vivo immune response to M. tuberculosis. We describe computational models that can be used to study (a) immunomodulation with the cytokines tumor necrosis factor and interleukin 10, (b) oral and inhaled antibiotics, and (c) the effect of vaccination.

Graphical abstract: A multi-scale approach to designing therapeutics for tuberculosis

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Publication details

The article was received on 17 Dec 2014, accepted on 19 Apr 2015 and first published on 20 Apr 2015


Article type: Paper
DOI: 10.1039/C4IB00295D
Author version available: Download Author version (PDF)
Citation: Integr. Biol., 2015,7, 591-609
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    A multi-scale approach to designing therapeutics for tuberculosis

    J. J. Linderman, N. A. Cilfone, E. Pienaar, C. Gong and D. E. Kirschner, Integr. Biol., 2015, 7, 591
    DOI: 10.1039/C4IB00295D

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