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Themed collection Molecular Medicine and Neurodegenerative Diseases

12 articles
Editorial

Molecular medicine and neurodegenerative diseases

Guest editors Christopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson and Mi Hee Lim introduce the Molecular medicine and neurodegenerative diseases themed issue of Chemical Society Reviews.

Graphical abstract: Molecular medicine and neurodegenerative diseases
Open Access Review Article

Biological metals and metal-targeting compounds in major neurodegenerative diseases

Metals are functionally essential, but redistribute in neurodegenerative disease where they induce protein aggregates, catalyze radical formation, and lose bioavailability.

Graphical abstract: Biological metals and metal-targeting compounds in major neurodegenerative diseases
Review Article

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

Increasing levels of glucose responsive O-GlcNAcylation of proteins in Alzheimer disease mouse models decreases the toxicity of tau and Aβ.

Graphical abstract: O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
Review Article

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

The review highlights the progress in the design and development of BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

Graphical abstract: BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease
Review Article

Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids

This review describes the development of inhibitors for endocannabinoid metabolism and their potential therapeutic benefit.

Graphical abstract: Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids
Open Access Review Article

Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease

The use radioactive copper and technetium complexes as amyloid imaging agents, the use of luminescent metal complexes as non-conventional probes of amyloid formation and the potential of metal complexes to be inhibitors of amyloid toxicity are discussed.

Graphical abstract: Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease
Review Article

Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs

Aggregation of small Aβ oligomers into common β-sheet rich annular structural motifs is responsible for Alzheimer's disease.

Graphical abstract: Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs
Review Article

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain

Overproduction of nitric oxide by neuronal nitric oxide synthase is implicated in neurodegenerative diseases and neuropathic pain; inhibition is therapeutically desirable.

Graphical abstract: Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain
Review Article

P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases

The P7C3 compounds emerged from an in vivo screen and were found to protect neurons in models of neurodegenerative disease.

Graphical abstract: P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases
Tutorial Review

Cholesterol and metal ions in Alzheimer's disease

This review describes the possible involvement of cholesterol and metal ions in AD neuropathogenesis in both individual and interconnected manners.

Graphical abstract: Cholesterol and metal ions in Alzheimer's disease
Tutorial Review

PET/SPECT imaging agents for neurodegenerative diseases

Amyvid/PET imaging of a living brain detects β-amyloid plaque deposition, a risk factor for developing Alzheimer's disease.

Graphical abstract: PET/SPECT imaging agents for neurodegenerative diseases
Tutorial Review

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease.

Graphical abstract: Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease
12 articles

About this collection

This Chemical Society Reviews themed issue on molecular medicine and neurodegenerative diseases was guest edited by Christopher Chang (UC Berkeley), Mi Hee Lim (University of Michigan), Benjamin Cravatt (Scripps Research Institute) and Doug Johnson (Pfizer Neuroscience). This issue will contain a series of invited reviews from prominent scientists working in all aspects of neurodegenerative disorders, including, but not limited to: diagnostics/imaging, therapeutics, drug delivery, tool or method development, mechanistic or structural studies of neurodegeneration, and pathologically relevant biological pathways and factors. New articles will be added to this collection as they are published.

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