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Themed collection Emerging Investigators

53 articles
Cover

Front cover

Graphical abstract: Front cover
From the themed collection: Emerging Investigators
Cover

Inside front cover

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From the themed collection: Emerging Investigators
Cover

Inside back cover

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From the themed collection: Emerging Investigators
Cover

Back cover

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From the themed collection: Emerging Investigators
Front/Back Matter

Contents list

From the themed collection: Emerging Investigators
Editorial

Emerging investigators 2015

Welcome to this Analytical Methods themed issue on emerging investigators. Lane Baker and Ryan Bailey discuss the work showcased.

Graphical abstract: Emerging investigators 2015
From the themed collection: Emerging Investigators
Profile

Contributors to the emerging investigators issue

Analytical Methods profiles the emerging investigators featuring work in this themed issue.

Graphical abstract: Contributors to the emerging investigators issue
From the themed collection: Emerging Investigators
Perspective

Analytical chemistry research at primarily undergraduate institutions: training tomorrow's investigators

This perspective presents challenges, benefits, and recent advances from research at primarily undergraduate institutions.

Graphical abstract: Analytical chemistry research at primarily undergraduate institutions: training tomorrow's investigators
From the themed collection: Emerging Investigators
Minireview

Recent developments in electrochemical paper-based analytical devices

This mini-review discusses recent advances in electrochemical paper-based analytical devices with an emphasis on applications of traditional electrochemical methods.

Graphical abstract: Recent developments in electrochemical paper-based analytical devices
From the themed collection: Microfluidics Research 2015-2016
Minireview

Monitoring of chemical transformations by mass spectrometry

During the last several decades, mass spectrometry (MS) has rapidly developed as a practical technique that can be used to monitor chemical reactions and investigate reaction mechanisms.

Graphical abstract: Monitoring of chemical transformations by mass spectrometry
From the themed collection: Emerging Investigators
Tutorial Review

Multimodal scanning probe imaging: nanoscale chemical analysis from biology to renewable energy

Multimodal scanning probe microscopy enables analysis of not only surface topography, but also surface chemistry, electrical, magnetic, and mechanical properties.

Graphical abstract: Multimodal scanning probe imaging: nanoscale chemical analysis from biology to renewable energy
From the themed collection: Emerging Investigators
Tutorial Review

Electrochemical nanoprobes for the chemical detection of neurotransmitters

Neurotransmitters, acting as chemical messengers, play an important role in neurotransmission, which governs many functional aspects of nervous system activity.

Graphical abstract: Electrochemical nanoprobes for the chemical detection of neurotransmitters
From the themed collection: Emerging Investigators
Tutorial Review

A review of traditional and emerging methods to characterize lipid–protein interactions in biological membranes

Lipid–protein interactions are essential for modulating membrane protein structures and biological functions in the cell plasma membrane. In this review we describe the salient features of classical and emerging methodologies for studying protein–lipid interactions and their limitations.

Graphical abstract: A review of traditional and emerging methods to characterize lipid–protein interactions in biological membranes
From the themed collection: Emerging Investigators
Tutorial Review

Photoluminescent nanosensors for intracellular detection

Main strategies for detecting changes in intracellular parameters (pH, ion concentration, reactive oxygen species, temperature, RNA levels and enzymatic activity) with photoluminescent nanosensors are reviewed in detail.

Graphical abstract: Photoluminescent nanosensors for intracellular detection
From the themed collection: Emerging Investigators
Open Access Tutorial Review

Emergence of tunable resistive pulse sensing as a biosensor

A review and tutorial on tunable resistive pulse sensors used as biosensors.

Graphical abstract: Emergence of tunable resistive pulse sensing as a biosensor
From the themed collection: Emerging Investigators
Critical Review

DNA–bare gold affinity interactions: mechanism and applications in biosensing

Sequence-dependent non-thiolated DNA–gold affinity interaction for biosensing applications, and the underlying principles governing these interactions are comprehensively reviewed.

Graphical abstract: DNA–bare gold affinity interactions: mechanism and applications in biosensing
From the themed collection: Recent Review Articles
Critical Review

Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review

With their unique supermacroporous architecture, polyHIPEs (high internal phase emulsions) and cryogels have huge potential as analytical separation stationary phases.

Graphical abstract: Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review
From the themed collection: Recent Review Articles
Critical Review

Emerging techniques for the in situ analysis of reaction intermediates on photo-electrochemical interfaces

We offer a perspective on how new in situ methods enable the chemically-sensitive, time-resolved and spatially-resolved exploration of semiconductor surface photo(electro)chemistry.

Graphical abstract: Emerging techniques for the in situ analysis of reaction intermediates on photo-electrochemical interfaces
From the themed collection: Recent Review Articles
Critical Review

Tracking single particle rotation: probing dynamics in four dimensions

Direct visualization and tracking of small particles at high spatial and temporal resolution provides a powerful approach to probing complex dynamics and interactions in chemical and biological processes.

Graphical abstract: Tracking single particle rotation: probing dynamics in four dimensions
From the themed collection: Recent Review Articles
Critical Review

Combined electrochemical-topographical imaging: a critical review

This review critically analyses the state-of-the-art in correlative electrochemical-topographical imaging, focusing on AFM, shear-force, ion conductance, and electrochemical positional feedback.

Graphical abstract: Combined electrochemical-topographical imaging: a critical review
From the themed collection: Recent Review Articles
Critical Review

Sensing in aqueous medium: mechanism and its application in the field of molecular recognition

Chemosensor development and their mechanisms are detailed for molecular recognition.

Graphical abstract: Sensing in aqueous medium: mechanism and its application in the field of molecular recognition
From the themed collection: Recent Review Articles
Open Access Communication

Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation

Extreme supercharging of proteins yields significant performance gains for the direct characterization of protein sequences by electron capture dissociation mass spectrometry.

Graphical abstract: Electron capture dissociation of extremely supercharged protein ions formed by electrospray ionisation
From the themed collection: Emerging Investigators
Open Access Communication

Microfluidic protein crystallisation controlled using spontaneous emulsification

Microdroplet-based protein crystallisation using spontaneous emulsification is proposed and demonstrated. The dependency of crystal number in a single microdroplet on the surfactant concentration is discussed.

Graphical abstract: Microfluidic protein crystallisation controlled using spontaneous emulsification
From the themed collection: Microfluidics Research 2015-2016
Paper

Single-cell migration as studied by scanning electrochemical microscopy

An SECM based analytical method to study single-cell biomechanics is reported to differentiate between migrating and stationary cancer cells.

Graphical abstract: Single-cell migration as studied by scanning electrochemical microscopy
From the themed collection: Emerging Investigators
Paper

Quantifying aptamer–protein binding via thermofluorimetric analysis

Homogeneous, aptamer-based protein quantification via thermofluorimetric analysis (TFA) permits subtraction of autofluorescence in biological samples.

Graphical abstract: Quantifying aptamer–protein binding via thermofluorimetric analysis
From the themed collection: Emerging Investigators
Open Access Paper

Microelemental characterisation of Aboriginal Australian natural Fe oxide pigments

This manuscript presents the first comprehensive microcharacterisation of Fe oxide minerals used in Aboriginal Australian mineral pigments.

Graphical abstract: Microelemental characterisation of Aboriginal Australian natural Fe oxide pigments
From the themed collection: Emerging Investigators
Paper

Quantitation of thiol metabolites from mammalian cells using fluorous tagging and HILIC-MS

Oxidative stress diminishes reduced thiols by decreasing their production or by forming disulfide bonds.

Graphical abstract: Quantitation of thiol metabolites from mammalian cells using fluorous tagging and HILIC-MS
From the themed collection: Emerging Investigators
Paper

A density-controlled scaffolding strategy for covalent functionalization of carbon-fiber microelectrodes

We describe a covalent functionalization method for creating density-controlled selective adsorption sites on carbon-fiber microelectrodes.

Graphical abstract: A density-controlled scaffolding strategy for covalent functionalization of carbon-fiber microelectrodes
From the themed collection: Emerging Investigators
Open Access Paper

Multiplexing strategy for simultaneous detection of redox-, phospho- and total proteome – understanding TOR regulating pathways in Chlamydomonas reinhardtii

A multiplexing 2DE-based approach for parallel analysis of redox-, phospho- and total-proteome is presented and applied to the study of Chlamydomonas TOR pathway.

Graphical abstract: Multiplexing strategy for simultaneous detection of redox-, phospho- and total proteome – understanding TOR regulating pathways in Chlamydomonas reinhardtii
From the themed collection: Emerging Investigators
Paper

Exploratory analysis of avocado extracts by GC-MS: new insights into the avocado fruit ripening process

Herewith the usefulness of a gas chromatography-electron ionization-quadrupole mass spectrometry (GC-EI-Q MS) methodology has been evaluated for the identification of potential ripening or variety markers of the avocado fruit.

Graphical abstract: Exploratory analysis of avocado extracts by GC-MS: new insights into the avocado fruit ripening process
From the themed collection: Emerging Investigators
Paper

Rapid determination of multiclass fungicides in wine by low-temperature plasma (LTP) ambient ionization mass spectrometry

LTP-MS/MS is a rapid method for the qualitative and semi-quantitative determination of pesticides in wines.

Graphical abstract: Rapid determination of multiclass fungicides in wine by low-temperature plasma (LTP) ambient ionization mass spectrometry
From the themed collection: Emerging Investigators
Open Access Paper

Towards improving the robustness of electrochemical gas sensors: impact of PMMA addition on the sensing of oxygen in an ionic liquid

An ionic liquid–polymer gel was found to improve the robustness of an integrated planar electrode system for portable oxygen gas-sensing applications.

Graphical abstract: Towards improving the robustness of electrochemical gas sensors: impact of PMMA addition on the sensing of oxygen in an ionic liquid
From the themed collection: Emerging Investigators
Paper

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

Paper microfluidic devices were explored to perform the colorimetric determination of nitrite in saliva, sausage, ham, preservative water and river water samples with no statistical difference from a reference method.

Graphical abstract: Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms
From the themed collection: Emerging Investigators
Paper

Fluorescent microRNA biosensors: a comparison of signal generation to quenching

Many microRNA biosensor platforms regard fluorescence signal generation as superior to quenching; however, the two methods are comparable rather than competitive.

Graphical abstract: Fluorescent microRNA biosensors: a comparison of signal generation to quenching
From the themed collection: Emerging Investigators
Paper

Hydrodynamic nonadhesive cell retention in a microfluidic circuit for stressless suspension culture

Cell collection based on deterministic lateral displacement (DLD) and cell circulation with a loop channel are two component technologies for stressless cell retention which have been developed with a view to working toward suspension culture in a microfluidic channel.

Graphical abstract: Hydrodynamic nonadhesive cell retention in a microfluidic circuit for stressless suspension culture
From the themed collection: Microfluidics Research 2015-2016
Open Access Paper

Multiplexed single-cell in situ RNA analysis by reiterative hybridization

A novel method to quantify the identities, positions, and copy numbers of a large number of different RNA species in single cells has been developed by reiterative cycles of target hybridization, fluorescence imaging and photobleaching.

Graphical abstract: Multiplexed single-cell in situ RNA analysis by reiterative hybridization
From the themed collection: Emerging Investigators
Paper

A spectral sieve-based strategy for sensing inorganic and organic traces on solid surfaces using laser-induced breakdown spectroscopy

Profiting the correlation between emission signals to detect residues on solid surfaces when laser ablation faces inspection of suspicious targets.

Graphical abstract: A spectral sieve-based strategy for sensing inorganic and organic traces on solid surfaces using laser-induced breakdown spectroscopy
From the themed collection: Emerging Investigators
Paper

Self-assembly pipette tip-based cigarette filters for micro-solid phase extraction of ketoconazole cis-enantiomers in urine samples followed by high-performance liquid chromatography/diode array detection

A simple stereoselective HPLC/DAD method was developed for the determination of ketoconazole (KTZ) cis-enantiomers in human urine.

Graphical abstract: Self-assembly pipette tip-based cigarette filters for micro-solid phase extraction of ketoconazole cis-enantiomers in urine samples followed by high-performance liquid chromatography/diode array detection
From the themed collection: Emerging Investigators
Paper

Rapid screening of antibody–antigen binding using dynamic light scattering (DLS) and gold nanoparticles

Antigen-mediated aggregation of antibody–gold nanoparticle conjugates is detected with dynamic light scattering to evaluate antibody–antigen binding.

Graphical abstract: Rapid screening of antibody–antigen binding using dynamic light scattering (DLS) and gold nanoparticles
From the themed collection: Emerging Investigators
Paper

A magnetically tuneable piezoresistive sensor for direct, in situ strain measurements in Li-ion batteries

Strain from Li-alloying anodes in operando is directly detected using generic battery components as a piezoresistive sensor. Magnetic-field alignment effectively enhances the sensitivity of this sensor.

Graphical abstract: A magnetically tuneable piezoresistive sensor for direct, in situ strain measurements in Li-ion batteries
From the themed collection: Emerging Investigators
Paper

Analysis of fluid film behaviour using dynamic wetting at a smooth and roughened surface

The dynamic wetting technique is described and used to create and aid in analysis of ultrathin (1–5 nm) films on vertically aligned, planar silver substrates of varying microscopic roughness (RMS roughness between 1 and 7 nm).

Graphical abstract: Analysis of fluid film behaviour using dynamic wetting at a smooth and roughened surface
From the themed collection: Emerging Investigators
Paper

Site-selective characterization of Src homology 3 domain molecular recognition with cyanophenylalanine infrared probes

We present site-selective CNPhe labeling combined with FT IR spectroscopy as a fast, minimally-perturbative, reproducible approach to characterize protein microenvironments.

Graphical abstract: Site-selective characterization of Src homology 3 domain molecular recognition with cyanophenylalanine infrared probes
From the themed collection: Emerging Investigators
Paper

Enhancing the mass spectrometric identification of membrane proteins by combining chemical and enzymatic digestion methods

Combining chemical and enzymatic digestion methods proved to be extremely effective for mass-spectrometry (MS)-based membrane protein analysis.

Graphical abstract: Enhancing the mass spectrometric identification of membrane proteins by combining chemical and enzymatic digestion methods
From the themed collection: Emerging Investigators
Paper

Monitoring the clandestine synthesis of methamphetamine in real-time with ambient sampling, portable mass spectrometry

In this paper, an ambient sampling, portable mass spectrometer coupled to a selection on ambient ionization methods was used to perform real-time reaction monitoring of clandestine methamphetamine syntheses.

Graphical abstract: Monitoring the clandestine synthesis of methamphetamine in real-time with ambient sampling, portable mass spectrometry
From the themed collection: Hot articles in Analytical Methods 2015
Paper

Green detection of the olive fruit fly pest by the direct determination of its sexual pheromone

Bactrocera oleae Gmelin, the olive fruit fly, is considered a serious pest in the cultivation of olive trees since the larvae feed on the fruit damaging the productivity and quality of the final products (olive fruit and olive oil).

Graphical abstract: Green detection of the olive fruit fly pest by the direct determination of its sexual pheromone
From the themed collection: Emerging Investigators
Paper

Chemometric analysis of MALDI mass spectrometric images of three-dimensional cell culture systems

As imaging mass spectrometry (IMS) has grown in popularity in recent years, the applications of this technique have become increasingly diverse.

Graphical abstract: Chemometric analysis of MALDI mass spectrometric images of three-dimensional cell culture systems
From the themed collection: Emerging Investigators
Paper

Investigating optimum sample preparation for infrared spectroscopic serum diagnostics

Biofluids, such as serum and plasma, represent an ideal medium for disease diagnosis due to their non-invasive character, ease of collection, that can be performed worldwide, and their fundamental involvement in human functions.

Graphical abstract: Investigating optimum sample preparation for infrared spectroscopic serum diagnostics
From the themed collection: Emerging Investigators
Paper

Analysis of bacterial plasmid DNA by solid-phase microextraction

A polymeric ionic liquid sorbent coating is applied in the extraction of two different plasmids from a mixture of E. coli transformants using solid-phase microextraction.

Graphical abstract: Analysis of bacterial plasmid DNA by solid-phase microextraction
From the themed collection: Emerging Investigators
Paper

Food safety: how analytical chemists ensure it

Nowadays consumer concerns related to food safety are increasing and analytical chemists should provide suitable analytical tools to fulfil international legislation and ensure that foodstuff is adequate to be consumed.

Graphical abstract: Food safety: how analytical chemists ensure it
From the themed collection: Emerging Investigators
Paper

A strategy for minimizing background signal in autoinductive signal amplification reactions for point-of-need assays

This paper describes a small molecule signal amplification reagent and an assay strategy that incorporates in situ signal amplification with minimal production of background signal.

Graphical abstract: A strategy for minimizing background signal in autoinductive signal amplification reactions for point-of-need assays
From the themed collection: Microfluidics Research 2015-2016
Paper

A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC

A multi-location peak parking protocol was developed for a non-destructive assessment of the axial heterogeneity of in situ modified monoliths. This was tested on a column with a surface coverage density gradient along the length of the monolithic rod. Qualitative changes in band broadening were observed and were consistent with theoretical studies.

Graphical abstract: A non-destructive test to assess the axial heterogeneity of in situ modified monoliths for HPLC
From the themed collection: Emerging Investigators
Paper

Improved monitoring of P. aeruginosa on agar plates

A disposable electrochemical assay that is integrated with standard culture plates for the selective and specific detection of Pseudomonas aeruginosa.

Graphical abstract: Improved monitoring of P. aeruginosa on agar plates
From the themed collection: Hot articles in Analytical Methods 2015
Paper

Ultrasound-assisted digestion of biodiesel samples for determination of metals by stripping voltammetry

Room-temperature ultrasound-assisted digestion of biodiesel for stripping voltammetry of metals with adequate recovery values (94–108%) and low residual carbon content is demonstrated.

Graphical abstract: Ultrasound-assisted digestion of biodiesel samples for determination of metals by stripping voltammetry
From the themed collection: Emerging Investigators
53 articles

About this collection

This is a collection of papers consisting of invited contributions including perspectives, reviews, and original research articles from emerging investigators in the analytical sciences. Guest Edited by Lane Baker and Ryan Bailey. New articles will be added to this collection as they are published.

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