Issue 4, 2022

Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones

Abstract

Herein we present a diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines catalyzed by a Rh(I) catalyst. This reaction provides a practical method to obtain valuable chiral α-amino ketones with excellent diastereoselectivity, featuring operational simplicity, mild reaction conditions and a broad substrate scope.

Graphical abstract: Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones

Supplementary files

Article information

Article type
Research Article
Submitted
17 Nov 2021
Accepted
22 Dec 2021
First published
22 Dec 2021

Org. Chem. Front., 2022,9, 1016-1022

Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones

C. Wang, L. Zhou, J. Qiu, K. Yang and Q. Song, Org. Chem. Front., 2022, 9, 1016 DOI: 10.1039/D1QO01721G

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