Issue 17, 2016
From the journal:

Organic & Biomolecular Chemistry

Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives†

Jia-hua Chen,a   Zi-cong Chen,a   Hong Zhao,a   Ting Zhang,a   Wei-juan Wang,a   Yong Zou,a   Xue-jing Zhang*a  and  Ming Yana  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: zhangxj33@mail.sysu.edu.cn
Fax: +86-20-39943051
Tel: +86-20-39943051

Abstract

KOt-Bu/DMF promoted intramolecular addition of diarylmethanols to imines was developed. A series of 2,3-disubstituted indoles was obtained in good yields. A reaction mechanism of radical cyclization and subsequent dehydration is proposed.

Graphical abstract: Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives

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Article information

DOI
https://doi.org/10.1039/C6OB00423G
Article type
Paper
Submitted
24 Feb 2016
Accepted
31 Mar 2016
First published
31 Mar 2016

Org. Biomol. Chem., 2016,14, 4071-4076

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Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives

J. Chen, Z. Chen, H. Zhao, T. Zhang, W. Wang, Y. Zou, X. Zhang and M. Yan, Org. Biomol. Chem., 2016, 14, 4071 DOI: 10.1039/C6OB00423G

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