Fc-fusion mimetics†
Abstract
The Fc-fusion mimetic RpR was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.