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Issue 6, 2016
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Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

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Abstract

The host immune response to foreign materials is a major hurdle for implanted medical devices. To control this response, modulation of macrophage behavior has emerged as a promising strategy, given their prominent role in inflammation and wound healing. Towards this goal, we explore the effect of biomimetic multi-scale wrinkles on macrophage adhesion and expression of phenotype markers. We find that macrophages elongate along the direction of the uniaxial wrinkles made from shape memory polymers, and express more arginase-1 and IL-10, and less TNF-α, suggesting polarization towards an alternatively activated, anti-inflammatory phenotype. Materials were further implanted in the subcutaneous space of mice and tissue surrounding the material evaluated by histology and immunohistochemistry. We found that material surface topography altered the distribution of collagen deposition in the adjacent tissue, with denser collagen tissue observed near flat materials when compared to wrinkled materials. Furthermore, cells surrounding wrinkled materials exhibited higher arginase-1 expression. Together these data suggest that wrinkled material surfaces promote macrophage alternative activation, and may influence the foreign body response to implants.

Graphical abstract: Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

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Publication details

The article was received on 28 Mar 2016, accepted on 15 Apr 2016 and first published on 29 Apr 2016


Article type: Communication
DOI: 10.1039/C6BM00224B
Citation: Biomater. Sci., 2016,4, 948-952
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    Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles

    T. Wang, T. U. Luu, A. Chen, M. Khine and W. F. Liu, Biomater. Sci., 2016, 4, 948
    DOI: 10.1039/C6BM00224B

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