Issue 96, 2012
From the journal:

Chemical Communications

Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function†

Adam G. Newman,a   Anna L. Vagstad,a   Katherine Belecki,a   Jonathan R. Scheererb  and  Craig A. Townsend*a  

* Corresponding authors

a Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, USA
E-mail: ctownsend@jhu.edu

b Department of Chemistry, College of William & Mary, Williamsburg, USA

Abstract

The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.

Graphical abstract: Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function

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Article information

DOI
https://doi.org/10.1039/C2CC36010A
Article type
Communication
Submitted
19 Aug 2012
Accepted
16 Oct 2012
First published
29 Oct 2012

Chem. Commun., 2012,48, 11772-11774

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Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function

A. G. Newman, A. L. Vagstad, K. Belecki, J. R. Scheerer and C. A. Townsend, Chem. Commun., 2012, 48, 11772 DOI: 10.1039/C2CC36010A

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