Issue 10, 2011
From the journal:

Chemical Communications

An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity†

Shuna Liu,a   Ping Wu,a   Wen Li,a   Hui Zhanga  and  Chenxin Cai*a  

* Corresponding authors

a Jiangsu Key Laboratory of Power Batteries, Jiangsu Key Laboratory of Biofunctional Materials, Laboratory of Electrochemistry, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
E-mail: cxcai@njnu.edu.cn, chenxincai@hotmail.com
Fax: +86 25 85891767
Tel: +86 25 85891780

Abstract

This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.

Graphical abstract: An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity

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Article information

DOI
https://doi.org/10.1039/C0CC05153E
Article type
Communication
Submitted
24 Nov 2010
Accepted
07 Jan 2011
First published
21 Jan 2011

Chem. Commun., 2011,47, 2844-2846

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An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity

S. Liu, P. Wu, W. Li, H. Zhang and C. Cai, Chem. Commun., 2011, 47, 2844 DOI: 10.1039/C0CC05153E

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