Issue 7, 2005
From the journal:

Chemical Communications

Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide†

Sami Halila,a   Trinidad Velasco,a   Pierre De Clercqa  and  Annemieke Madder*a  

* Corresponding authors

a Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, S4, Gent, Belgium
E-mail: annemieke.madder@Ugent.be
Fax: +32-9-2644498
Tel: +32-9-2644472

Abstract

Oligonucleotides containing a furan modified internal nucleoside have been synthesized; selective in situ oxidation of the furan moiety to a reactive enal species in the presence of a complementary DNA strand gives rise to fast and efficient formation of an interstrand cross-link.

Graphical abstract: Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide

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Article information

DOI
https://doi.org/10.1039/B415092A
Article type
Communication
Submitted
30 Sep 2004
Accepted
15 Nov 2004
First published
04 Jan 2005

Chem. Commun., 2005, 936-938

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Fine-tuning furan toxicity: fast and quantitative DNA interchain cross-link formation upon selective oxidation of a furan containing oligonucleotide

S. Halila, T. Velasco, P. D. Clercq and A. Madder, Chem. Commun., 2005, 936 DOI: 10.1039/B415092A

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