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Issue 7, 2016
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The synthesis of di-carboxylate esters using continuous flow vortex fluidics

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Abstract

A vortex fluidic device (VFD) is effective in mediating the synthesis of di-esters at room temperature. Processing under ambient conditions allows for a simple and efficient synthesis, whilst operating under continuous flow addresses scalability. The rotational speed of the sample tube and the flow rate were critical variables during reaction optimization, and this relates to the behaviour of the fluid flow at a molecular level. Whilst at specific rotational speeds the tube imparts a vibrational response into the fluid flow, the flow rate dictates residence time and the ability to maintain high levels of shear stress. The combination of mechanically induced vibrations, rapid micromixing, high levels of shear stress and water evaporation results in yields up to 90% for 3.25 minutes or less residence time. These results are key for devising greener and more efficient processes both mediated by the VFD and other continuous flow platforms.

Graphical abstract: The synthesis of di-carboxylate esters using continuous flow vortex fluidics

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Publication details

The article was received on 16 Oct 2015, accepted on 30 Nov 2015 and first published on 01 Dec 2015


Article type: Paper
DOI: 10.1039/C5GC02494C
Author version available: Download Author version (PDF)
Citation: Green Chem., 2016,18, 2193-2200
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    The synthesis of di-carboxylate esters using continuous flow vortex fluidics

    J. Britton, S. B. Dalziel and C. L. Raston, Green Chem., 2016, 18, 2193
    DOI: 10.1039/C5GC02494C

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