Issue 28, 2019

Design of a Zn-MOF biosensor via a ligand “lock” for the recognition and distinction of S-containing amino acids

Abstract

Two new 2D Zn(II) metal–organic frameworks (MOFs) {[Zn2(L)22-O)(H2O)3]·3DMA}n (Zn-1) and [Zn2(L)2(2,2′-bipy)(μ2-O)(H2O)2]n (Zn-2) (H2L = 2,5-thiophene dicarboxylic acid, bipy = 2,2′-dipyridyl) were designed and synthesized. Through the strategy of introducing bipy as a “lock”, Zn-1 was transferred to Zn-2via a crystal-to-crystal process, which showed significantly enhanced solvent and air stability compared to that of Zn-1. Without post modification, Zn-2 was used as an electrode modified material to construct sensors for the electrochemical recognition and distinction of S-containing amino acids, including L-cysteine, L-methionine and L-cystine.

Graphical abstract: Design of a Zn-MOF biosensor via a ligand “lock” for the recognition and distinction of S-containing amino acids

Supplementary files

Article information

Article type
Communication
Submitted
01 Mar 2019
Accepted
07 Mar 2019
First published
07 Mar 2019

Chem. Commun., 2019,55, 4059-4062

Design of a Zn-MOF biosensor via a ligand “lock” for the recognition and distinction of S-containing amino acids

X. Wu, Y. Liu, P. Feng, X. Wei, G. Yang, X. Qiu and J. Ma, Chem. Commun., 2019, 55, 4059 DOI: 10.1039/C9CC01701A

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