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Issue 16, 2018
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A single-electrode electrochemical system for multiplex electrochemiluminescence analysis based on a resistance induced potential difference

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Abstract

Developing low-cost and simple electrochemical systems is becoming increasingly important but still challenged for multiplex experiments. Here we report a single-electrode electrochemical system (SEES) using only one electrode not only for a single experiment but also for multiplex experiments based on a resistance induced potential difference. SEESs for a single experiment and multiplex experiments are fabricated by attaching a self-adhesive label with a hole and multiple holes onto an ITO electrode, respectively. This enables multiplex electrochemiluminescence analysis with high sensitivity at a very low safe voltage using a smartphone as a detector. For the multiplex analysis, the SEES using a single electrode is much simpler, cheaper and more user-friendly than conventional electrochemical systems and bipolar electrochemical systems using electrode arrays. Moreover, SEESs are free from the electrochemiluminescent background problem from driving electrodes in bipolar electrochemical systems. Since numerous electrodes and cover materials can be used to fabricate SEESs readily and electrochemistry is being extensively used, SEESs are very promising for broad applications, such as drug screening and high throughput analysis.

Graphical abstract: A single-electrode electrochemical system for multiplex electrochemiluminescence analysis based on a resistance induced potential difference

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Publication details

The article was received on 25 Jan 2018, accepted on 17 Mar 2018 and first published on 19 Mar 2018


Article type: Edge Article
DOI: 10.1039/C8SC00410B
Citation: Chem. Sci., 2018,9, 3911-3916
  • Open access: Creative Commons BY license
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    A single-electrode electrochemical system for multiplex electrochemiluminescence analysis based on a resistance induced potential difference

    W. Gao, K. Muzyka, X. Ma, B. Lou and G. Xu, Chem. Sci., 2018, 9, 3911
    DOI: 10.1039/C8SC00410B

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