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Asymmetric [4 + 2] Cycloadditions with 3-Furfural Derivatives and α-Cyano-α,β-Unsaturated Ketones

Abstract

The dearomatizative dienamine-type intermediates between 2-benzyl-3-furfurals and a chiral secondary amine underwent asymmetric [4 + 2] cycloadditions with α-cyano-chalcone-type substrates, affording the tetrahydrobenzofurans having dense substitutions and multiple stereogenic centers with high to outstanding results (up to 92% yield, >99% ee, >19:1 dr).

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Publication details

The article was received on 05 Apr 2018, accepted on 16 May 2018 and first published on 17 May 2018


Article type: Research Article
DOI: 10.1039/C8QO00351C
Citation: Org. Chem. Front., 2018, Accepted Manuscript
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    Asymmetric [4 + 2] Cycloadditions with 3-Furfural Derivatives and α-Cyano-α,β-Unsaturated Ketones

    C. Duan, X. He, W. Du and Y. Chen, Org. Chem. Front., 2018, Accepted Manuscript , DOI: 10.1039/C8QO00351C

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