Jump to main content
Jump to site search

Issue 8, 2018
Previous Article Next Article

A general and efficient Mn-catalyzed acceptorless dehydrogenative coupling of alcohols with hydroxides into carboxylates

Author affiliations

Abstract

The direct oxidation of alcohols into carboxylic acids is an essential reaction for the synthesis of bulky and fine chemicals. Most current processes require the use of either strong and toxic oxidants or the presence of pressurized oxygen. Herein, we report a sustainable manganese-catalyzed acceptorless dehydrogenative coupling of alcohols with alkaline water to form carboxylates generating H2 as the sole by-product. This is a general applicable and efficient non-noble metal catalyzed dehydrogenative transformation of alcohols into carboxylates. The reaction proceeded selectively in the presence of a well-defined manganese pincer complex at a very low catalyst loading. A wide range of carboxylic acids (46 examples) were synthesized with high yields and excellent functional group tolerance. Mechanistic studies including control experiments, NMR spectroscopy, and X-ray crystallography identified the resting state and key intermediates in the catalytic cycle.

Graphical abstract: A general and efficient Mn-catalyzed acceptorless dehydrogenative coupling of alcohols with hydroxides into carboxylates

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jan 2018, accepted on 31 Jan 2018 and first published on 02 Feb 2018


Article type: Research Article
DOI: 10.1039/C8QO00023A
Citation: Org. Chem. Front., 2018,5, 1248-1256
  •   Request permissions

    A general and efficient Mn-catalyzed acceptorless dehydrogenative coupling of alcohols with hydroxides into carboxylates

    Z. Shao, Y. Wang, Y. Liu, Q. Wang, X. Fu and Q. Liu, Org. Chem. Front., 2018, 5, 1248
    DOI: 10.1039/C8QO00023A

Search articles by author

Spotlight

Advertisements