Jump to main content
Jump to site search

Issue 12, 2018
Previous Article Next Article

Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: synthesis of quinolactacide and marinamide

Author affiliations

Abstract

A facile synthetic route has been developed for the preparation of pyrrolizinone derivatives employing N-allyl imides as starting materials. The nucleophilic addition of a vinyl Grignard reagent/RCM/elimination sequence afforded pyrrolizinones in good yields and has been applied for the preparation of naturally occurring quinolactacide and marinamide.

Graphical abstract: Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: synthesis of quinolactacide and marinamide

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jan 2018, accepted on 28 Feb 2018 and first published on 28 Feb 2018


Article type: Paper
DOI: 10.1039/C8OB00260F
Citation: Org. Biomol. Chem., 2018,16, 2125-2133
  •   Request permissions

    Preparation of pyrrolizinone derivatives via sequential transformations of cyclic allyl imides: synthesis of quinolactacide and marinamide

    M. Simic, G. Tasic, P. Jovanovic, M. Petkovic and V. Savic, Org. Biomol. Chem., 2018, 16, 2125
    DOI: 10.1039/C8OB00260F

Search articles by author

Spotlight

Advertisements