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Dopant-dependent crystallization and photothermal effect of Sb-doped SnO2 nanoparticles as stable theranostic nanoagents for tumor ablation

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Abstract

Ideal theranostic nanoagents should be “all-in-one” type nanocrystals that have a single-semiconductor component and all-required properties (such as imaging and photothermal effects), but most semiconductor nanocrystals do not have these required properties. With SnO2 as a model of a typical wide-band semiconductor, we report the tuning from UV-responsive SnO2 to blue SnO2 nanocrystals with imaging ability and a Sb-doping-dependent photothermal effect. Sb-Doped SnO2 nanocrystals were prepared by heating SbCl3 and SnCl4 in benzyl alcohol solution through a facile solvothermal route. When the SbCl3/SnCl4 molar ratio increases from 0 to 0.2/1, the obtained samples exhibit an increased photothermal effect under the irradiation of a 1064 nm laser, accompanied by gradually decreased size and crystallinity. With a further increase of the molar ratio from 0.3/1.0 to 1.0/1.0, the resulting samples demonstrate the tetragonal SnO2 phase with amorphous-like compounds and they show no obvious enhancement of a photothermal effect. After a surface modification with biological molecules, the optimized Sb0.2-SnO2 nanocrystals demonstrated good stability and a high photothermal conversion efficiency of 48.3% as well as low cytotoxicity. When Sb0.2-SnO2 was injected into a tumor of mice, the tumor could be simultaneously detected by X-ray computed tomography (CT) and photoacoustic (PA) imaging, and then thermally ablated when exposed to a 1064 nm laser. Therefore, these nanocrystals can be used as “all-in-one” type nanoagents for imaging guided photothermal ablation of tumors under the irradiation of a laser in the second bio-transparent window.

Graphical abstract: Dopant-dependent crystallization and photothermal effect of Sb-doped SnO2 nanoparticles as stable theranostic nanoagents for tumor ablation

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Publication details

The article was received on 25 Nov 2017, accepted on 02 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7NR08811F
Citation: Nanoscale, 2018, Advance Article
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    Dopant-dependent crystallization and photothermal effect of Sb-doped SnO2 nanoparticles as stable theranostic nanoagents for tumor ablation

    N. Yu, C. Peng, Z. Wang, Z. Liu, B. Zhu, Z. Yi, M. Zhu, X. Liu and Z. Chen, Nanoscale, 2018, Advance Article , DOI: 10.1039/C7NR08811F

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