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Issue 7, 2018
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Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

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Abstract

Covering: up to the end of 2017

The roles played by Rieske non-heme iron-dependent oxygenases in natural product biosynthesis are reviewed, with particular focus on experimentally characterised examples. Enzymes belonging to this class are known to catalyse a range of transformations, including oxidative carbocyclisation, N-oxygenation, C-hydroxylation and C–C desaturation. Examples of such enzymes that have yet to be experimentally investigated are also briefly described and their likely functions are discussed.

Graphical abstract: Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

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Publication details

The article was received on 15 Jan 2018 and first published on 13 Apr 2018


Article type: Highlight
DOI: 10.1039/C8NP00004B
Citation: Nat. Prod. Rep., 2018,35, 622-632
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    Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

    C. Perry, Emmanuel L. C. de los Santos, L. M. Alkhalaf and G. L. Challis, Nat. Prod. Rep., 2018, 35, 622
    DOI: 10.1039/C8NP00004B

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