Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Hitomi Nakamura; Yudai Matsuda; Ikuro Abe

doi:10.1039/C7NP00055C

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Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Hitomi Nakamura,^a Yudai Matsuda

*^ab and Ikuro Abe

*^a

Author affiliations

* Corresponding authors

^a Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: abei@mol.f.u-tokyo.ac.jp

^b Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, China
E-mail: ymatsuda@cityu.edu.hk

Abstract

Covering: up to 2018

Non-heme iron enzymes are a versatile family of oxygenases that catalyze remarkable types of chemistry. This review highlights the intriguing chemistry of non-heme iron enzymes, especially those utilizing α-ketoglutarate (α-KG) as a co-substrate, in fungal secondary metabolism and aims to summarize how nature diversifies and complexifies natural products.

Graphical abstract: Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

This article is part of the themed collection: Metalloenzymes in Natural Product Biosynthetic Pathways

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Article information

DOI: https://doi.org/10.1039/C7NP00055C
Article type: Review Article
Submitted: 19 Nov 2017
First published: 07 Mar 2018

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Nat. Prod. Rep., 2018,35, 633-645

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Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

H. Nakamura, Y. Matsuda and I. Abe, Nat. Prod. Rep., 2018, 35, 633 DOI: 10.1039/C7NP00055C

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Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

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