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Issue 3, 2018
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Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

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Abstract

The inadvertent errors in the lattice energy calculations of the polymorphs reported in our previous article (CrystEngComm, 2009, 11, 1823–1827) were rectified. Form I (Refcode: QULLUF) was found to be the most thermodynamically stable polymorph by slurry experiments even though it has marginally higher lattice energy than the other two polymorphs.

Graphical abstract: Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

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Publication details

The article was received on 14 Nov 2017, accepted on 13 Dec 2017 and first published on 13 Dec 2017


Article type: Letter
DOI: 10.1039/C7CE01979C
Citation: CrystEngComm, 2018,20, 373-374
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    Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

    S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2018, 20, 373
    DOI: 10.1039/C7CE01979C

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