Issue 9, 2009

Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

Abstract

The first example of a trimorphic cocrystal involving two active pharmaceutical ingredients (APIs), ethenzamide and gentisic acid, is reported; metastable polymorphs convert to the stable form upon solid-state grinding; pharmaceutical cocrystals involving two or more APIs have potential relevance to combination drugs.

Graphical abstract: Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2009
Accepted
29 May 2009
First published
19 Jun 2009

CrystEngComm, 2009,11, 1823-1827

Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823 DOI: 10.1039/B904616J

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