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Black TiO2 based nanoprobes for T1-weighted MRI guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells

Abstract

At present, transmembrane glycoprotein CD133 high expressed pancreatic cancer stem cells (PCSCs), with the features of chemotherapeutic/radiotherapeutic resistance and exclusively tumorigenic potential, have been considered as primary cause of metastasis and recurrence in pancreatic cancer, and therefore is one of effective targets in the disease treatment. Furthermore, with the launching of precision medicine, multifunctional nanoprobes have been applied as a valid strategy for magnetic resonance imaging (MRI) guided photothermal therapy (PTT) of pancreatic cancer. In this research, with the aim of precise MRI guided PTT in CD133 high expressed PCSCs, novel bTiO2-Gd-CD133mAb nanoprobes are designed and successfully prepared by loading Gd-DOTA and CD133 monoclonal antibodies on black TiO2 nanoparticles . It is very interesting that r1 relaxivity value of the nanoprobes is 34.394 Mm-1 s-1, about 7.5 times than that of commercial Magnevist (4.5624 Mm-1 s-1), which indicates that the nanoprobes are potential MRI T1 contrast agents with excellent performance. Herein, CD133 high expressed PANC-1 cells are selected and verified as PCSCs model. In vitro experiments demonstrate that the nanoprobes exhibit active-targeting ability in the PANC-1 cells, and consequently can specially enhance T1-weigthed MR imaging and 808nm near-infrared (NIR) triggered PTT efficiency in the PCSCs model. Our study not only provides a new strategy for effective treatment of pancreatic cancer and its’ stem cells, but also further broadens application of black TiO2 in the field of cancer theranostics.

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Publication details

The article was received on 25 Apr 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8BM00454D
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Black TiO2 based nanoprobes for T1-weighted MRI guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells

    S. Wang, W. Ren, J. H. Wang, Z. Jiang, M. Saeed, L. Zhang, A. Li and A. Wu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00454D

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