Jump to main content
Jump to site search


Fast determination of cocaine and some common adulterants in seized cocaine samples by capillary electrophoresis with capacitively coupled contactless conductivity detection

Abstract

The determination of cocaine and common adulterants in seized cocaine samples can be used to identify their possible production area and traffic routes. In this paper, capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-C4D) was used for fast simultaneous determination of cocaine (COC), procaine (PRO), levamisole (LEV) and lidocaine (LID) (38 injections per hour). The separation was achieved using a fused silica capillary (50 cm total length – 40 cm effective length, 50 μm i.d.) and a background electrolyte composed by boric acid/3,4-dimethoxycinnamic acid (20/10 mmol L−1) with pH adjusted to 8.4 with sodium hydroxide. Linear working ranges (r ≥ 0.996) were obtained from 100 to 900 µmol L-1 for COC, and from 50 to 450 µmol L-1 for PRO, LEV, and LID. The limits of detection were 10, 4, 6, and 7 µmol L-1 for PRO, COC, LEV and LID, respectively. In addition, the proposed method also provided adequate intra (≤ 2.3%) and inter-day (≤ 4%) precisions, as well as satisfactory recovery values for spiked seized cocaine samples (from 96% to 103%).

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Apr 2018, accepted on 30 Apr 2018 and first published on 30 Apr 2018


Article type: Paper
DOI: 10.1039/C8AY00795K
Citation: Anal. Methods, 2018, Accepted Manuscript
  •   Request permissions

    Fast determination of cocaine and some common adulterants in seized cocaine samples by capillary electrophoresis with capacitively coupled contactless conductivity detection

    E. M. Richter, M. C. Marra, B. M. D. C. Costa, R. A. A. Munoz, M. H. Santana, A. O. Maldaner, E. D. Botelho and W. K. T. Coltro, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00795K

Search articles by author

Spotlight

Advertisements