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Simple and economic elaboration of high purity CaCO3 particles for bone graft applications by spray pyrolysis technique

Abstract

Materials for bone grafting are today a major health stake. The existing synthetic materials only partially answer to the requirements for such uses and don’t provide a real alternative solution to the classsical way consisting in the reuse of natural osseous materials, known to create other problems. In the present work, we have prepared calcium carbonate powders by spray pyrolysis in the perspective to realize ideal and multi-purposed bricks to form bone graft materials, by bottom-up approaches, using classical techniques. The chemical reactions involved in the synthesis process consist in the thermal decomposition of calcium acetate. This precursor, a classical food additive, is known to be non toxic, easy to use and very cheap. Morphological and chemical characterizations were conducted on the obtained materials. Depending on the pyrolysis temperature, we observed partial decomposition of calcium acetate or lime formation. An annealing step is consequently required to finalize the transformation. Finaly, it appears that annealed products are pure calcite particles, having a spherical morphology and possessing a low dispersity in the micron size range. These particles exhibit an original internal structure, reinforcing them and ensuring the preservation of their morpholgical characteristics during sintering process. Furthermore, a porosity compatible with drug carrier capabilities was measured on the obtained products. All these qualities allow to consider a multi-purpose use of these particles in almost all types of bone graft materials.

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Publication details

The article was received on 01 Mar 2017, accepted on 12 Jul 2017 and first published on 13 Jul 2017


Article type: Paper
DOI: 10.1039/C7TB00586E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Simple and economic elaboration of high purity CaCO3 particles for bone graft applications by spray pyrolysis technique

    D. Neumeyer, C. Venturini, N. Ratel-Ramond, M. Verelst and A. Gourdon, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00586E

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