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Issue 69, 2017, Issue in Progress
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α-Alkylation of ketimines using visible light photoredox catalysis

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Abstract

A novel α-alkylation of N-diphenylphosphinoyl ketimines with α-bromocarbonyl compounds has been accomplished using visible light photoredox catalysis. The reaction proceeds under remarkably mild conditions: at 35 °C, in 20 hours, under blue light irradiation (1 W), in the presence of a tertiary amine and catalytic amounts of Ru- and Ni-based complexes. Chemoselective transformation of the products provides access to 1,4-dicarbonyl compounds, protected GABA analogues and γ-lactams.

Graphical abstract: α-Alkylation of ketimines using visible light photoredox catalysis

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Publication details

The article was received on 21 Aug 2017, accepted on 22 Aug 2017 and first published on 11 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA09248B
Citation: RSC Adv., 2017,7, 43655-43659
  • Open access: Creative Commons BY-NC license
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    α-Alkylation of ketimines using visible light photoredox catalysis

    A. Franchino, A. Rinaldi and D. J. Dixon, RSC Adv., 2017, 7, 43655
    DOI: 10.1039/C7RA09248B

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