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Catalytic asymmetric synthesis of hetero-substituted oxindoles

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Abstract

Chiral disubstituted oxindoles represent an important family of bioactive molecules. The construction of asymmetric quaternary carbon in the cyclopentane ring is therefore a challenging problem for organic chemists. In the last few years, many papers have appeared on asymmetric catalytic methods for the synthesis of these compounds and the literature on spirocyclic derivatives, 3-substituted-3-hydroxyoxindoles and 3-substituted-3-aminooxindoles has been largely reviewed. The literature on other hetero-substituted oxindoles has not been fully reviewed after 2011. This review aims to fill this gap by covering the literature on these topics until the end of 2016. A special section is also devoted to indoline-thiones.

Graphical abstract: Catalytic asymmetric synthesis of hetero-substituted oxindoles

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Publication details

The article was received on 05 Jun 2017, accepted on 04 Jul 2017 and first published on 05 Jul 2017


Article type: Review Article
DOI: 10.1039/C7QO00446J
Citation: Org. Chem. Front., 2017, Advance Article
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    Catalytic asymmetric synthesis of hetero-substituted oxindoles

    R. Dalpozzo, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00446J

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