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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Abstract

Here we describe a one-pot, three-enzyme, cascade involving a cytochrome P450 monooxygenase, an alcohol dehydrogenase and a reductive aminase for the synthesis of secondary amines from cycloalkanes. Amine product concentrations of up to 19.6 mM were achieved. The preparative scale amination of cyclohexane was also demonstrated with a space–time yield of 2 g L−1 d−1.

Graphical abstract: A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

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Publication details

The article was received on 17 Oct 2017, accepted on 10 Nov 2017 and first published on 10 Nov 2017


Article type: Communication
DOI: 10.1039/C7OB02569F
Citation: Org. Biomol. Chem., 2017, Advance Article
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    A biocatalytic cascade for the amination of unfunctionalised cycloalkanes

    M. Tavanti, J. Mangas-Sanchez, S. L. Montgomery, M. P. Thompson and N. J. Turner, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB02569F

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