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Issue 41, 2017
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Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds

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Abstract

A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage (0.1 mL DMSO/0.2 mmol scale), wide substrate scope (34 examples), mild reaction conditions (room temperature) and high chemical yield (up to 99%).

Graphical abstract: Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds

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Publication details

The article was received on 16 Sep 2017, accepted on 04 Oct 2017 and first published on 04 Oct 2017


Article type: Communication
DOI: 10.1039/C7OB02319G
Citation: Org. Biomol. Chem., 2017,15, 8705-8708
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    Diversity-driven and facile 1,3-dipolar cycloaddition to access dispirooxindole-imidazolidine scaffolds

    Y. Qian, P. Xia, J. Li, Q. Zhao, J. Xiao, H. Xiang and H. Yang, Org. Biomol. Chem., 2017, 15, 8705
    DOI: 10.1039/C7OB02319G

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