Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential

Abstract

Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC₅₀ values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.