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Issue 35, 2017
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An organocatalytic cis-selective approach to bicyclic δ-lactones

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Abstract

A new, cis-selective, approach for the synthesis of bicyclic δ-lactones bearing a fused cyclohex-2-en-1-one moiety is described. The strategy utilizes a cascade reactivity of cyclic 1,3-diketones and 3-arylidenefuran-2(3H)-ones with the butenolide-ring-opening reaction enabling the construction of the δ-lactone framework. It benefits from broad scope, high enantioselectivity and excellent cis-diastereoselectivity.

Graphical abstract: An organocatalytic cis-selective approach to bicyclic δ-lactones

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Publication details

The article was received on 28 Jun 2017, accepted on 11 Aug 2017 and first published on 11 Aug 2017


Article type: Communication
DOI: 10.1039/C7OB01570D
Citation: Org. Biomol. Chem., 2017,15, 7286-7289
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    An organocatalytic cis-selective approach to bicyclic δ-lactones

    D. Kowalczyk and Ł. Albrecht, Org. Biomol. Chem., 2017, 15, 7286
    DOI: 10.1039/C7OB01570D

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