CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides

Die Li; Xin-Xing Wu; Tingyu Gao; Baoguo Li; Shufeng Chen

doi:10.1039/C7OB01838J

CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides

Die Li,^a Xin-Xing Wu,^a Tingyu Gao,^a Baoguo Li*^a and Shufeng Chen*^a

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* Corresponding authors

^a Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, People's Republic of China
E-mail: shufengchen@imu.edu.cn, baoguol@sohu.com

Abstract

An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. The distinctive features of this protocol include the use of an inexpensive copper salt as a catalyst, simple and readily available starting materials, and ligand-free conditions. An important application of this method to the synthesis of 1,3-diene substituted benzoxazoles has also been achieved.

Supplementary files

Publication details

The article was received on 25 Jul 2017, accepted on 22 Aug 2017 and first published on 22 Aug 2017

Article type: Communication

DOI: 10.1039/C7OB01838J

Citation: Org. Biomol. Chem., 2017,15, 7282-7285

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CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides

D. Li, X. Wu, T. Gao, B. Li and S. Chen, Org. Biomol. Chem., 2017, 15, 7282
DOI: 10.1039/C7OB01838J
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Organic & Biomolecular Chemistry

CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides

Abstract

Supplementary files

Publication details

CuCl-Catalyzed direct C–H alkenylation of benzoxazoles with allyl halides

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