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Issue 26, 2017
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1,2-Arylalkylation of N-(arylsulfonyl)acrylamides using aliphatic aldehydes as the alkyl source

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Abstract

A metal-free decarbonylative arylalkylation of N-(arylsulfonyl)acrylamides using aliphatic aldehydes as the alkyl radical source was developed, providing a series of α-aryl-β-alkylamides in moderate to good yields. In this reaction, concomitant alkylation, aryl migration and desulfonylation were involved.

Graphical abstract: 1,2-Arylalkylation of N-(arylsulfonyl)acrylamides using aliphatic aldehydes as the alkyl source

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Publication details

The article was received on 23 May 2017, accepted on 19 Jun 2017 and first published on 19 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01260H
Citation: Org. Biomol. Chem., 2017,15, 5476-5479
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    1,2-Arylalkylation of N-(arylsulfonyl)acrylamides using aliphatic aldehydes as the alkyl source

    J. Yu, R. Chen, J. Zhu and J. Cheng, Org. Biomol. Chem., 2017, 15, 5476
    DOI: 10.1039/C7OB01260H

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